beta-Alanine

Modify Date: 2024-01-01 23:47:50

beta-Alanine Structure
beta-Alanine structure
Common Name beta-Alanine
CAS Number 107-95-9 Molecular Weight 89.093
Density 1.2±0.1 g/cm3 Boiling Point 237.1±23.0 °C at 760 mmHg
Molecular Formula C3H7NO2 Melting Point 202 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 97.2±22.6 °C

 Use of beta-Alanine


β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

 Names

Name β-alanine
Synonym More Synonyms

 beta-Alanine Biological Activity

Description β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Cells treated with β-alanine display significantly suppressed basal and peak ECAR (aerobic glycolysis), with simultaneous increase in glucose transporter 1 (GLUT1). Additionally, cells treated with β-alanine exhibit significantly reduced basal and peak OCR (oxidative metabolism), which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis. Suppression of glycolytic and oxidative metabolism by β-alanine results in the reduction of total metabolic rate, although cell viability is not affected.β-alanine is shown to reduce both cell migration and proliferation without acting in a cytotoxic fashion. Moreover, β-alanine significantly increases malignant cell sensitivity to doxorubicin, suggesting a potential role as a co-therapeutic agent[1].
References

[1]. Vaughan RA, et al. β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer. 2014 Jan 24;13:14.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 237.1±23.0 °C at 760 mmHg
Melting Point 202 °C (dec.)(lit.)
Molecular Formula C3H7NO2
Molecular Weight 89.093
Flash Point 97.2±22.6 °C
Exact Mass 89.047676
PSA 63.32000
LogP -0.86
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.463
Storage condition Store at RT.
Water Solubility H2O: 1 M at 20 °C, clear, colorless

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UA2369200
HS Code 29224920

 Synthetic Route

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles125

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Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

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Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds ...

 Synonyms

3-Aminopropanoic acid
beta-alanine
3-Aminopropionic Acid
EINECS 203-536-5
MFCD00008200
β-Alanine
H-β-Ala-OH
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