Glyphosate

Modify Date: 2024-01-02 12:05:33

Glyphosate Structure
Glyphosate structure
 Common Name Glyphosate
CAS Number 1071-83-6 Molecular Weight 169.073
Density 1.7±0.1 g/cm3 Boiling Point 465.8±55.0 °C at 760 mmHg
Molecular Formula C3H8NO5P Melting Point 230 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 235.5±31.5 °C
Symbol GHS05 GHS09
GHS05, GHS09		 Signal Word Danger

 Use of Glyphosate


Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[1].

 Names

Name Glyphosate
Synonym More Synonyms

 Glyphosate Biological Activity

Description Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[1].
Related Catalog
In Vitro Glyphosate is a high-efficiency, low-toxicity, broad-spectrum herbicide. The residues of glyphosate-based herbicides are frequent pollutants in the environment. Glyphosate exposure could interfere with mouse oocyte maturation by generating oxidative stress and early apoptosis.Glyphosate induces early apoptosis and autophagy in mouse oocytes[2].
References

[1]. Greim H, et al. Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45(3):185-208.

[2]. Zhang JW, et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec;237:124435.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 465.8±55.0 °C at 760 mmHg
Melting Point 230 °C (dec.)(lit.)
Molecular Formula C3H8NO5P
Molecular Weight 169.073
Flash Point 235.5±31.5 °C
Exact Mass 169.014008
PSA 116.67000
LogP -2.36
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.529
Water Solubility 1.2 g/100 mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC1075000
CHEMICAL NAME :
Glycine, N-(phosphonomethyl)-
CAS REGISTRY NUMBER :
1071-83-6
LAST UPDATED :
199712
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C3-H8-N-O5-P
MOLECULAR WEIGHT :
169.09
WISWESSER LINE NOTATION :
QV1M1PQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
2143 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - fibrosis (interstitial) Lungs, Thorax, or Respiration - fibrosing alveolitis
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 29,91,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1214 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Gastrointestinal - hypermotility, diarrhea
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 10,103,1991
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction) Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 29,91,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4873 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,319,1978
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>12200 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A222,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
235 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1000(Sp Iss 1),148,198
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1568 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,319,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1000(Sp Iss 1),148,198
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972- Volume(issue)/page/year: 7,6,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
7940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A222,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>4640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,459,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
153 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3135
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22500 mg/kg/90D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
HCKHDV Huanjing Kexue. Environmental Sciences. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1976- Adopted vol. no. with Vol. 1, 1980. Volume(issue)/page/year: 5(2),52,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
435 gm/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3135

 Safety Information

Symbol GHS05 GHS09
GHS05, GHS09
Signal Word Danger
Hazard Statements H318-H411
Precautionary Statements P273-P280-P305 + P351 + P338 + P310-P391-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R41;R51/53
Safety Phrases S26-S39-S61-S2
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS MC1075000
HS Code 2931900041

 Synthetic Route

 Customs

HS Code 2931900041
Summary 2931900041 2-((phosphonomethyl)amino)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:6.5%。general tariff:30.0%

 Articles110

More Articles
The herbicide glyphosate causes behavioral changes and alterations in dopaminergic markers in male Sprague-Dawley rat.

Neurotoxicology 46 , 79-91, (2015)

Glyphosate (Glyph) is the active ingredient of several herbicide formulations. Reports of Glyph exposure in humans and animal models suggest that it may be neurotoxic. To evaluate the effects of Glyph...

Development of a multi-residue method in a fetal matrix: analysis of meconium.

Anal. Bioanal. Chem 406(30) , 7785-97, (2014)

Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method ...

Development of liquid chromatography methods coupled to mass spectrometry for the analysis of substances with a wide variety of polarity in meconium.

Talanta 138 , 231-9, (2015)

Meconium is the first fecal excretion of newborns. This complex accumulative matrix allows assessing the exposure of the fetus to xenobiotics during the last 6 months of pregnancy. To determine the ev...

 Synonyms

Roundup
N-phosphonomethylglycine acid
EINECS 213-997-4
Glycine, N-(phosphonomethyl)-
2-((Phosphonomethyl)amino)acetic acid
Glyphosate
(Carboxymethylamino)methylphosphonic acid
[(Phosphonomethyl)amino]acetic acid
Glyphodin A
MFCD00055350
Glysate
N-Phosphomethylglycine
Forsat
Glyphosate CT
Glialka
N-(Phosphonomethyl)glycine
Herbatop
(Phosphonomethyl)glycine
Accord
Folusen
Glialka 36
phosphonomethyl glycine
Phorsat
Rebel Garde
Glifocas
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