Hexaethylene glycol dimethyl ether

Modify Date: 2024-01-05 14:10:07

Hexaethylene glycol dimethyl ether Structure
Hexaethylene glycol dimethyl ether structure
Common Name Hexaethylene glycol dimethyl ether
CAS Number 1072-40-8 Molecular Weight 310.38400
Density 1.02g/cm3 Boiling Point 359ºC at 760mmHg
Molecular Formula C14H30O7 Melting Point N/A
MSDS N/A Flash Point 136.5ºC

 Use of Hexaethylene glycol dimethyl ether


Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-methoxy-2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethane
Synonym More Synonyms

 Hexaethylene glycol dimethyl ether Biological Activity

Description Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.02g/cm3
Boiling Point 359ºC at 760mmHg
Molecular Formula C14H30O7
Molecular Weight 310.38400
Flash Point 136.5ºC
Exact Mass 310.19900
PSA 64.61000
LogP 0.36220
Vapour Pressure 5.08E-05mmHg at 25°C
Index of Refraction 1.433

 Safety Information

HS Code 2901100000

 Customs

HS Code 2901100000
Summary 2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

 Synonyms

1,17-Dimethoxy-3,6,9,12,15-pentaoxa-heptadecan
2,5,8,11,14,17,20-heptaoxahenicosane
Hexaaethylenglykol-dimethylaether
2,5,8,11,14,17,20-Heptaoxaheneicosane
O,O'-Dimethyl-hexaaethylenglykol
Hexaethylene glycol dimethyl ether
1,17-dimethoxy-3,6,9,12,15-pentaoxa-heptadecane
EINECS 214-006-8
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