Triethylene glycol dimethyl ether

Modify Date: 2026-07-04 14:01:19

Triethylene glycol dimethyl ether Structure
Triethylene glycol dimethyl ether structure
 Common Name Triethylene glycol dimethyl ether
CAS Number 112-49-2 Molecular Weight 178.22600
Density 0.986 g/mL at 25 °C(lit.) Boiling Point 216 °C(lit.)
Molecular Formula C8H18O4 Melting Point −45 °C(lit.)
MSDS Chinese USA Flash Point 231 °F
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Danger

Summary: Triglyme, also known as triethylene glycol dimethyl ether, has a CAS number of 112-49-2, with a molecular formula of C8H18O4 and a molecular weight of 178.22600. It is a transparent colorless liquid with a slight air-like odor, with a melting point of -45 °C and a boiling point of 216 °C. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name triglyme
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 0.986 g/mL at 25 °C(lit.)
Boiling Point 216 °C(lit.)
Melting Point −45 °C(lit.)
Molecular Formula C8H18O4
Molecular Weight 178.22600
Flash Point 231 °F
Exact Mass 178.12100
PSA 36.92000
LogP 0.31240
Vapour density >4.7 (vs air)
Index of Refraction n20/D 1.423(lit.)
InChIKey YFNKIDBQEZZDLK-UHFFFAOYSA-N
SMILES COCCOCCOCCOC
Storage condition Refrigerator

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XF0665000
CHEMICAL NAME :
2,5,8,11-Tetraoxadodecane
CAS REGISTRY NUMBER :
112-49-2
BEILSTEIN REFERENCE NO. :
1700630
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C8-H18-O4
MOLECULAR WEIGHT :
178.26
WISWESSER LINE NOTATION :
1O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB86-103215
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 31,53A,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB86-103215
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
28 gm/kg
SEX/DURATION :
female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,29,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3500 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-181657
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3500 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-181657
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3325 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,238,1992 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0064 No. of Facilities: 27 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 270 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H319-H360Df
Supplemental HS May form explosive peroxides.
Precautionary Statements P201-P280-P305 + P351 + P338-P308 + P313-P337 + P313
Hazard Codes T:Toxic;
Risk Phrases R19;R61;R62
Safety Phrases S53-S45
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS XF0665000
HS Code 2942000000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Methyl-PEG2-alcohol structure

Methyl-PEG2-alcohol

CAS#:111-77-3

~1%

1,2-dimethoxyethane structure

1,2-dimethoxyethane

CAS#:110-71-4

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

2-methoxyethanol structure

2-methoxyethanol

CAS#:109-86-4

Detail Learn More
Literature: EP1650181 A1, ; Page/Page column 3 ;
Dimethyl sulfate structure

Dimethyl sulfate

CAS#:77-78-1

Triethylene glycol structure

Triethylene glycol

CAS#:112-27-6

~0%

m-PEG3-OH structure

m-PEG3-OH

CAS#:112-35-6

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

Learn More
Literature: Surya Prakash Rao; Babu, Mohan; Desai, Avinash RSC Advances, 2014 , vol. 4, # 22 p. 11064 - 11072
1,1,2,2-tetrakis-(2-methoxy-ethoxy)-ethane structure

1,1,2,2-tetraki...

CAS#:86220-16-8

~%

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

Learn More
Literature: US2425042 , ;
methyl iodide structure

methyl iodide

CAS#:74-88-4

Triethylene glycol structure

Triethylene glycol

CAS#:112-27-6

~%

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

Learn More
Literature: Angewandte Chemie, , vol. 87, # 22 p. 812 - 813
ETHYLENE OXIDE structure

ETHYLENE OXIDE

CAS#:75-21-8

dimethyl ether structure

dimethyl ether

CAS#:115-10-6

~0%

1,2-dimethoxyethane structure

1,2-dimethoxyethane

CAS#:110-71-4

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

Detail Learn More
Literature: WO2005/87695 A1, ; Page/Page column 7-9 ;
dimethyl ether structure

dimethyl ether

CAS#:115-10-6

~%

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

diglyme structure

diglyme

CAS#:111-96-6

Me-PEG4-Me structure

Me-PEG4-Me

CAS#:143-24-8

Learn More
Literature: WO2006/134081 A1, ; Page/Page column 6 ;
Dimethyl sulfate structure

Dimethyl sulfate

CAS#:77-78-1

~%

Triethylene glycol dimethyl ether Structure

Triethylene gly...

CAS#:112-49-2

Learn More
Literature: Industrial and Engineering Chemistry, , vol. 29, p. 548 Chem. Zentralbl., , vol. 109, # I p. 4534

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2901100000
Summary 2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

 Articles10

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Phase III interlaboratory study of FETAX. Part 3. FETAX validation using 12 compounds with and without an exogenous metabolic activation system.

J. Appl. Toxicol. 19(6) , 447-72, (1999)

FETAX (Frog Embryo Teratogenesis Assay-Xenopus) is a 96-h whole-embryo developmental toxicity screening assay that can be used in ecotoxicology and in detecting mammalian developmental toxicants when ...

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Relative potency of four ethylene glycol ethers for induction of paw malformations in the CD-1 mouse.

Teratology 35(3) , 321-8, (1987)

Time-mated CD-1 mice were orally dosed on gestation day 11 (plug = 0) with distilled water (control) or one of four glycol ethers at a dose of 4 mmol/kg: ethylene glycol monomethyl ether (EGME, 304 mg...

 Triethylene glycol dimethyl etherBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293
Name: Adrenergic beta2 receptor (ADRB2) small molecule antagonists, cell-based qHTS assay
Source: 824
External Id: ADRB2713
Total 207, Current Page 1 of 21
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Dimethyltriglycol
EINECS 203-977-3
Triethylene glycol dimethyl ether
MFCD00008504
1,2-Bis(2-methoxyethoxy)ethane,Dimethyltriglycol,Triglyme
2,5,8,11-Tetraoxadodecane
1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
1,2-Bis(2-methoxyethoxy)ethane

 Triethylene glycol dimethyl ether | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of triglyme?
A: SMILES notation of triglyme is COCCOCCOCCOC.
Q: What are the storage conditions for triglyme?
A: Storage conditions for triglyme: Refrigerator.
Q: What is the safety information for triglyme?
A: Safety information for triglyme: S53-S45.
Q: What is the molecular formula of triglyme?
A: Molecular formula of triglyme is C8H18O4.
Q: What is the boiling point of triglyme?
A: Boiling point of triglyme is 216 °C(lit.).
Q: What is the LogP of triglyme?
A: LogP of triglyme is 0.31240.
Q: What is the CAS number of triglyme?
A: CAS number of triglyme is 112-49-2.
Q: What English synonyms does triglyme have?
A: English synonyms of triglyme: Dimethyltriglycol, EINECS 203-977-3, Triethylene glycol dimethyl ether, MFCD00008504, 1,2-Bis(2-methoxyethoxy)ethane,Dimethyltriglycol,Triglyme, 2,5,8,11-Tetraoxadodecane, 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane, 1,2-Bis(2-methoxyethoxy)ethane.
Q: What is the polar surface area (PSA) of triglyme?
A: Polar surface area (PSA) of triglyme is 36.92000.
Q: What is the melting point of triglyme?
A: Melting point of triglyme is −45 °C(lit.).

 Triethylene glycol dimethyl etherfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides Triethylene glycol dimethyl ether(CAS#:112-49-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Triethylene glycol dimethyl ether are included as well.>> amp version: Triethylene glycol dimethyl ether

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