diglyme

Modify Date: 2026-07-01 21:20:50

diglyme structure	Common Name	diglyme
	CAS Number	111-96-6	Molecular Weight	134.174
	Density	0.9±0.1 g/cm3	Boiling Point	159.8±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₄O₃	Melting Point	−64 °C(lit.)
	MSDS	Chinese USA	Flash Point	70.0±0.0 °C
	Symbol	GHS02, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	diglyme
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	159.8±0.0 °C at 760 mmHg
Melting Point	−64 °C(lit.)
Molecular Formula	C₆H₁₄O₃
Molecular Weight	134.174
Flash Point	70.0±0.0 °C
Exact Mass	134.094299
PSA	27.69000
LogP	-0.80
Vapour density	4.6 (vs air)
Vapour Pressure	3.2±0.2 mmHg at 25°C
Index of Refraction	1.394
InChIKey	SBZXBUIDTXKZTM-UHFFFAOYSA-N
SMILES	COCCOCCOC
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. May be air or light sensitive.
Water Solubility	Miscible

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

diglyme MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KN3339000

CHEMICAL NAME :: Ether, bis(2-methoxyethyl)

CAS REGISTRY NUMBER :: 111-96-6

BEILSTEIN REFERENCE NO. :: 1736101

LAST UPDATED :: 199806

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C6-H14-O3

MOLECULAR WEIGHT :: 134.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13680 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1100 ppm/6H

SEX/DURATION :: male 2 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 537 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 1000 ppm/5D (Continuous)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-138198 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0698 No. of Facilities: 27 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 191 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0698 No. of Facilities: 13 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 207 (estimated) No. of Female Employees: 52 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS08
Signal Word	Danger
Hazard Statements	H226-H360
Supplemental HS	May form explosive peroxides.
Precautionary Statements	P201-P210-P280-P308 + P313-P370 + P378
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic;
Risk Phrases	R10;R19;R60;R61
Safety Phrases	S53-S45
RIDADR	UN 3271 3/PG 3
WGK Germany	1
RTECS	KN3339000
Packaging Group	III
Hazard Class	3
HS Code	2909199090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:67-56-1 Methanol CAS#:111-77-3 Methyl-PEG2-alcohol CAS#:111-46-6 Diethylene glycol CAS#:109-86-4 2-methoxyethanol
CAS#:433-06-7 2,2,2-trifluoro... CAS#:353-83-3 2-Iodo-1,1,1-tr... CAS#:17178-10-8 2-Methoxyethyl ... CAS#:74-88-4 methyl iodide
CAS#:112-35-6 m-PEG3-OH CAS#:124-41-4 Sodium Methylate
DownStream 10
CAS#:496-14-0 Phthalane CAS#:493-05-0 Isochroman CAS#:36101-23-2 α-methoxy-α,α'-... CAS#:5707-27-7 propyl 4-(4-eth...
CAS#:926-02-3 tert-butyl viny... CAS#:93-58-3 Methyl benzoate CAS#:939-55-9 2-Chloroethyl B... CAS#:41406-00-2 3-Isopropoxyaniline
CAS#:1883-38-1 tripentylborane CAS#:123-91-1 1,4-Dioxane

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Diels-Alder functionalized carbon nanotubes for bone tissue engineering: in vitro/in vivo biocompatibility and biodegradability.

Nanoscale 7 , 9238-51, (2015)

The risk-benefit balance for carbon nanotubes (CNTs) dictates their clinical fate. To take a step forward at this crossroad it is compulsory to modulate the CNT in vivo biocompatibility and biodegrada...

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Salts of highly fluorinated weakly coordinating anions as versatile precursors towards hydrogen storage materials.

Dalton Trans. 44 , 19469-77, (2015)

We report the most recent results related to application of a metathetic pathway towards mixed-metal borohydrides. The synthetic protocol utilizes highly-fluorinated weakly coordinating anion salts as...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

diethyleneglycol dimethylether

Bis(2-methoxyethyl) Ether

diethylene glycol dimethyl ether

1-methoxyethoxy-2-methoxyethoxyethane

Dimethylcarbitol

DEG dibenzoate

bis-(2-methoxy ethyl)-ether

MFCD00008503

1-Methoxy-2-(2-methoxyethoxy)ethane

Benzo flex 2-45

diglyme

Bis-(2-benzoyloxy-aethyl)-aether

EINECS 203-924-4

diethyleneglycol dibenzoate

Bis(2-methoxyethyl) ether,AcroSeal,Extra Dry

bis-(2-benzoyloxy-ethyl)-ether

OXY BIS(2-ETHYL BENZOATE)

oxydiethylenedibenzoate

diethylenebenzylbenzoate

2-Methoxyethyl ether

DIGLYCOL DIBENZOATE

Dimethyldiglycol

Diaethylenglykol-dibenzoat

DEGDB

1O2O2O1

bis(methoxyethyl) ether

2,2-OXYBISETHANOLDIBENZOATE

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of diglyme?

A: Boiling point of diglyme is 159.8±0.0 °C at 760 mmHg.

Q: What is the safety information for diglyme?

A: Safety information for diglyme: S53-S45.

Q: How is the water solubility of diglyme?

A: Water solubility of diglyme: Miscible.

Q: What is the melting point of diglyme?

A: Melting point of diglyme is −64 °C(lit.).

Q: What is the SMILES notation of diglyme?

A: SMILES notation of diglyme is COCCOCCOC.

Q: What is the InChIKey of diglyme?

A: InChIKey of diglyme is SBZXBUIDTXKZTM-UHFFFAOYSA-N.

Q: What is the molecular weight of diglyme?

A: Molecular weight of diglyme is 134.174.

Q: What is the LogP of diglyme?

A: LogP of diglyme is -0.80.

Q: What is the molecular formula of diglyme?

A: Molecular formula of diglyme is C6H14O3.

Q: What are the upstream materials of diglyme?

A: Related upstream materials(CAS) of diglyme: 67-56-1;111-77-3;111-46-6;109-86-4;433-06-7;353-83-3;17178-10-8;74-88-4;112-35-6;124-41-4.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: diglyme
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Methoxyethyl ether
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Diethylene Glycol Dimethyl Ether
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥64/100g

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diglyme

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Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

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diglyme | FAQ

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.