4-Hydroxycoumarin

Modify Date: 2024-01-02 11:15:14

4-Hydroxycoumarin structure	Common Name	4-Hydroxycoumarin
	CAS Number	1076-38-6	Molecular Weight	162.142
	Density	1.4±0.1 g/cm3	Boiling Point	352.4±42.0 °C at 760 mmHg
	Molecular Formula	C₉H₆O₃	Melting Point	211-213 °C(lit.)
	MSDS	USA	Flash Point	165.4±20.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Hydroxycoumarin

4-Hydroxycoumarin, a coumarin derivative, is one of the most versatile heterocyclic scaffolds and is frequently applied in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin derivatives are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors[1].

Name	4-hydroxycoumarin
Synonym	More Synonyms

Description	4-Hydroxycoumarin, a coumarin derivative, is one of the most versatile heterocyclic scaffolds and is frequently applied in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin derivatives are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Mohammadi Ziarani G, et al. The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions. Mol Divers. 2019 Jan 29. doi: 10.1007/s11030-019-09918-7.

Density	1.4±0.1 g/cm3
Boiling Point	352.4±42.0 °C at 760 mmHg
Melting Point	211-213 °C(lit.)
Molecular Formula	C₉H₆O₃
Molecular Weight	162.142
Flash Point	165.4±20.7 °C
Exact Mass	162.031693
PSA	50.44000
LogP	1.60
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.660
Water Solubility	PRACTICALLY INSOLUBLE

4-Hydroxycoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100000

CHEMICAL NAME :: 2H-1-Benzopyran-2-one, 4-hydroxy-

CAS REGISTRY NUMBER :: 1076-38-6

BEILSTEIN REFERENCE NO. :: 0129768

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H6-O3

MOLECULAR WEIGHT :: 162.15

WISWESSER LINE NOTATION :: T66 BOVJ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,126,1960

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3100000
HS Code	29322980

Precursor 9
CAS#:118-93-4 Ortho-Hydroxyac... CAS#:105-58-8 Ethyl carbonate CAS#:31005-07-9 4-prop-2-enoxyc... CAS#:201230-82-2 carbon monoxide
CAS#:66530-08-3 3-carbethoxy-4-... CAS#:616-38-6 Dimethyl Carbonate CAS#:75-44-5 phosgene CAS#:141-82-2 Malonic acid
CAS#:108-95-2 Phenol
DownStream 10
CAS#:111222-29-8 2H-1-Benzopyran... CAS#:111222-28-7 4-(2-phenylethy... CAS#:10523-48-5 4-HYDROXY-2-OXO... CAS#:10475-15-7 2H-1-Benzopyran...
CAS#:10173-87-2 2,4-diphenyl-4H... CAS#:111222-22-1 9-chlorochromen... CAS#:109797-42-4 4-cyclohex-2-en... CAS#:111222-25-4 4-(BENZYLAMINO)...
CAS#:4865-84-3 2-(1,2-Benzisox... CAS#:66233-72-5 (6-fluoro-benzo...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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4-hydroxy-coumari

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Product Name: 4-Hydroxycoumarin
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China
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China
Product Name: 4-Hydroxycoumarin
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