KT5720

Modify Date: 2024-01-02 14:59:27

KT5720 structure	Common Name	KT5720
	CAS Number	108068-98-0	Molecular Weight	537.60600
	Density	1.49g/cm3	Boiling Point	715ºC at 760mmHg
	Molecular Formula	C₃₂H₃₁N₃O₅	Melting Point	N/A
	MSDS	USA	Flash Point	386.2ºC

Use of KT5720

KT5720 is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM[1][2].

Name	kt 5720
Synonym	More Synonyms

Description	KT5720 is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Metabolic Disease
Target	Ki: 60 nM (PKA)[1][2].
References	[1]. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. [2]. Murray A, et al. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal. 2008 Jun 3;1(22):re4.

Density	1.49g/cm3
Boiling Point	715ºC at 760mmHg
Molecular Formula	C₃₂H₃₁N₃O₅
Molecular Weight	537.60600
Flash Point	386.2ºC
Exact Mass	537.22600
PSA	94.72000
LogP	5.93440
Vapour Pressure	1.88E-21mmHg at 25°C
Index of Refraction	1.752

Hazard Codes	Xi
Risk Phrases	R36/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport

Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2.

Biochem. Pharmacol. 96 , 306-14, (2015)

Metastasis is the major cause of death in cancer patients. Elevated expression of cyclooxygenase-2 (COX-2) is observed in many human cancers and over-production of downstream prostaglandins (PGs) has ...

Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.

Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010)

The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cel...

Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.

Biochem. Biophys. Res. Commun. 456(1) , 167-72, (2015)

Gastrointestinal disorder is a common symptom induced by diverse pathophysiological conditions that include food tolerance, chemotherapy, and irradiation for therapy. Prostaglandin E2 (PGE2) level inc...

MFCD00132118