S32826

Modify Date: 2025-08-26 19:05:22

S32826 Structure
S32826 structure
Common Name S32826
CAS Number 1096770-84-1 Molecular Weight 397.49
Density 1.1±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H36NO4P Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of S32826


S32826 is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 inhibits LPA release from adipocytes[1].

 Names

Name S32826 disodium salt hydrate
Synonym More Synonyms

 S32826 Biological Activity

Description S32826 is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 inhibits LPA release from adipocytes[1].
Related Catalog
Target

Autotaxin:8.8 nM (IC50)

In Vitro S32826 (0.001-10 μM; 10 days) dose-dependently inhibits the release of lyso-phosphatidic acid (LPA) by 3T3-F442A adipocytes with an IC50 of 90 nM and a maximal inhibition of 80% at 500 nM[1]. S32826 (1 μM; 24 h) inhibits Dexamethasone-induced increases in autotaxin (ATX) mRNA expression in HTM cells and lysoPLD activity in conditioned media. S32826 inhibits Dexamethasone-induced the phosphorylation of MLC and cofilin, mRNA upregulation of COL1A1 and COL4A1, and expression of α-SMA, fibronectin and collagen-1 in the HTM cells[2].
In Vivo Topical application of S32826 (2-10 mM; 2 h-5 d) decreases intraocular pressure (IOP) in a dose- and time-dependent manner in rabbits[2]. S32826 (∼2 µM; single intracameral injection) reduces the IOP in rabbits, with the ocular hypotensive response lasting for more than 48 hrs[2]. S32826 (10 mg/kg; p.o., i.p., s.c., and i.v.) shows poor in vivo stability and/or bioavailability[1].
References

[1]. Ferry G, et, al. S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J Pharmacol Exp Ther. 2008 Dec;327(3):809-19.

[2]. Honjo M, et, al. Role of the Autotaxin-LPA Pathway in Dexamethasone-Induced Fibrotic Responses and Extracellular Matrix Production in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):21-30.

[3]. Iyer P, et, al. Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. PLoS One. 2012;7(8):e42627.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Molecular Formula C21H36NO4P
Molecular Weight 397.49
Exact Mass 397.238190
PSA 96.44000
LogP 5.00
Index of Refraction 1.536

 Safety Information

Hazard Codes Xi

 Synonyms

[4-(Tetradecanoylamino)benzyl]phosphonic acid
Phosphonic acid, [[4-[(1-oxotetradecyl)amino]phenyl]methyl]-
[4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt hydrate
[4-(tetradecanoylamino)phenyl]methylphosphonic acid
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