Tunicamycin

Modify Date: 2024-01-02 22:21:25

Tunicamycin Structure
Tunicamycin structure
Common Name Tunicamycin
CAS Number 11089-65-9 Molecular Weight 844.94 (n=10)
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C39H64N4O16(n=10) Melting Point 234 - 235ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of Tunicamycin


Tunicamycin is a N-acetylglucosamine containing antibiotic from Streptomyces lysosuperijkus which inhibits protein glycosylation.

 Names

Name tunicamycin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 234 - 235ºC
Molecular Formula C39H64N4O16(n=10)
Molecular Weight 844.94 (n=10)
PSA 311.82000
LogP 2.58
Index of Refraction 1.617
Storage condition 2~8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YO7980200
CHEMICAL NAME :
Tunicamycin
CAS REGISTRY NUMBER :
11089-65-9
LAST UPDATED :
199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
500 ug/kg
SEX/DURATION :
female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
4 ug/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,1148,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0225 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 80 (estimated) No. of Female Employees: 30 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300
Precautionary Statements P264-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+: Very toxic;
Risk Phrases 28
Safety Phrases 28-37/39-45
RIDADR UN 3462 6
WGK Germany 3
RTECS YO7980200
Packaging Group II
Hazard Class 6.1(a)
HS Code 29419090

 Articles69

More Articles
Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.

J. Biol. Chem. 290 , 14361-80, (2015)

Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy. The mecha...

RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.

Autophagy 11 , 975-94, (2015)

Although RIPK1 (receptor [TNFRSF]-interacting protein kinase 1) is emerging as a critical determinant of cell fate in response to cellular stress resulting from activation of death receptors and DNA d...

Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies.

J. Immunol. 195 , 5178-88, (2015)

B cell binding and cytotoxicity by human VH4-34-encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early response in a phase 1 trial for treatment of ...

 Synonyms

TUNICAMYCIN,STREPTOMYCES LYSOSUPERFICUS
MFCD00065709
Tunicamycin Streptomyces sp.
(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2S,3S,4S,5R,6S)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-3,4-dihydroxytetrahydro-2-furanyl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-12-methyl-2-tridecenamide
(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2S,3S,4S,5R,6S)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-12-methyltridec-2-enamide (non-preferred name)
TUNICAMYCIN
Top Suppliers:I want be here


Get all suppliers and price by the below link:

Tunicamycin suppliers


Price: $72/2mg

Reference only. check more Tunicamycin price