(-)-taxifolin

Modify Date: 2024-01-11 12:36:39

(-)-taxifolin Structure
(-)-taxifolin structure
Common Name (-)-taxifolin
CAS Number 111003-33-9 Molecular Weight 304.252
Density 1.7±0.1 g/cm3 Boiling Point 687.6±55.0 °C at 760 mmHg
Molecular Formula C15H12O7 Melting Point 232-234 ºC (ethanol )
MSDS N/A Flash Point 264.2±25.0 °C

 Use of (-)-taxifolin


(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

 Names

Name (-)-taxifolin
Synonym More Synonyms

 (-)-taxifolin Biological Activity

Description (-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
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References

[1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586.

[2]. Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Front Pharmacol. 2021 Jan 14;11:608511.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 687.6±55.0 °C at 760 mmHg
Melting Point 232-234 ºC (ethanol )
Molecular Formula C15H12O7
Molecular Weight 304.252
Flash Point 264.2±25.0 °C
Exact Mass 304.058289
LogP 1.82
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.763
Water Solubility Very slightly soluble (0.97 g/L) (25 ºC)

 Synonyms

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2S,3S)-
(-)-taxifolin
(-)-Dihydroquercetin
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