Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Taxifolin
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Purity: 98.0%
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China
Product Name: Taxifolin
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Taxifolin
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DC Chemicals Limited
China
Product Name: Taxifolin
Price: $280.0/20mg
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Taxifolin
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480-18-2

480-18-2 structure

480-18-2 structure

Name: Taxifolin
Chemical Name: (+)-taxifolin
CAS Number: 480-18-2
Molecular Formula: C₁₅H₁₂O₇
Molecular Weight: 304.252
Catalog: Biochemical Natural product
Create Date: 2018-08-08 18:58:57
Modify Date: 2024-01-02 17:59:31
Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM.

Name	(+)-taxifolin
Synonyms	EINECS 207-543-4 Dihydroquercetin (3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- Distylin (+)-Taxifolin (2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-trans)- 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2S,3S)- Taxifolin MFCD00006845 (-)-taxifolin Taxifoliol (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

Description	Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Research Areas >> Cancer Natural Products >> Flavonoids
Target	IC50: 193.3 μM (Collagenase)[1] Tyrosinase[1]
In Vitro	This is confirmed by the investigation of pure Taxifolin and (+)-Catechin against collagenase activity. Taxifolin exhibits significant inhibitory activity with an IC50 value of 193.3 μM while (+)-Catechin is not active[1]. Taxifolin is a ubiquitous bioactive constituent of foods and herbs. Taxifolin (dihydroquercetin) is a bioactive flavanonol commonly found in grapes, citrus fruits, onions, green tea, olive oil, wine, and many other foods, as well as several herbs (such as milk thistle, French maritime bark, Douglas fir bark, and Smilacis Glabrae Rhizoma)[2].
In Vivo	Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[2].
Animal Admin	Rats[2] Twelve male Sprague-Dawley rats (weighing 180-220 g) are used. The rats are randomly divided into two groups (six rats per group), a drug group and a blank group. Taxifolin is suspended in 0.5% CMC-Na solution and orally administered to the drug group at a dose of 200 mg/kg body weight, while blank group rats are orally administered 0.5% CMC-Na solution at the same volume. All rats are dosed once a day (at 9:00 a.m.) for 3 days.
References	[1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586. [2]. Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.

Density	1.7±0.1 g/cm3
Boiling Point	687.6±55.0 °C at 760 mmHg
Melting Point	230-233°C (dec.)
Molecular Formula	C₁₅H₁₂O₇
Molecular Weight	304.252
Flash Point	264.2±25.0 °C
Exact Mass	304.058289
PSA	127.45000
LogP	1.82
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.763
Storage condition	-20?C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK6920000

CHEMICAL NAME :: Flavanone, 3,3',4',5,7-pentahydroxy-

CAS REGISTRY NUMBER :: 480-18-2

BEILSTEIN REFERENCE NO. :: 0093548

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H12-O7

MOLECULAR WEIGHT :: 304.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 985 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1 gm/L/48H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LK6920000
HS Code	2932999099

Precursor 8
1298135-47-3 574749-31-8 36804-13-4 29838-67-3
154-23-4 85443-49-8 574749-29-4 40672-47-7
DownStream 8
480-18-2 855-97-0 117-39-5 552-58-9
23567-23-9 12798-57-1 29106-51-2 29080-58-8

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%