L-penicillamine

Modify Date: 2024-01-02 09:45:21

L-penicillamine Structure
L-penicillamine structure
 Common Name L-penicillamine
CAS Number 1113-41-3 Molecular Weight 149.211
Density 1.2±0.1 g/cm3 Boiling Point 251.8±35.0 °C at 760 mmHg
Molecular Formula C5H11NO2S Melting Point 206ºC (dec.)
MSDS Chinese USA Flash Point 106.1±25.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of L-penicillamine


L-Penicillamine is a medication primarily used for the treatment of Wilson's disease. It is also used for people with kidney stones who have high urine cystine levels, rheumatoid arthritis, copper poisoning, and lead poisoning. It is taken by mouth. Common side effects include rash, loss of appetite, nausea, diarrhea, and low blood white blood cell levels. Other serious side effects include liver problems, obliterative bronchiolitis, and myasthenia gravis. It is not recommended in people with lupus erythematosus. Use during pregnancy may result in harm to the baby. Penicillamine works by binding heavy metals such that they can be removed from the body in the urine.

 Names

Name L-penicillamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 251.8±35.0 °C at 760 mmHg
Melting Point 206ºC (dec.)
Molecular Formula C5H11NO2S
Molecular Weight 149.211
Flash Point 106.1±25.9 °C
Exact Mass 149.051056
PSA 102.12000
LogP 0.93
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.528

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV9445500
CHEMICAL NAME :
Valine, 3-mercapto-, L-
CAS REGISTRY NUMBER :
1113-41-3
BEILSTEIN REFERENCE NO. :
1722374
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H11-N-O2-S
MOLECULAR WEIGHT :
149.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
4 umol/plate
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,3725,1985 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,465,1979

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS YV9445500
HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

EINECS 214-203-9
L(+)-Penicillamine
2-Amino-3-mercapto-3-methylbutanoic acid
3-mercapto-L-valine
3-Sulfanyl-L-valine
L-β,β-Dimethylcysteine
L-Penicillamine
(R)-penicillamine
(±)-penicillamine
DL-Penicillamine
β, β-Dimethyl-DL-cysteine
β,β-Dimethyl-DL-cysteine
L-β-Mercaptovaline
(2R)-2-amino-3-mercapto-3-methyl-butyric acid
(2R)-2-amino-3-mercapto-3-methylbutanoic acid
3,3-Dimethyl-DL-cysteine
3-Sulfanylvaline
MFCD00064303
Valine, 3-mercapto-
α-AMINO-β-METHYL-β-MERCAPTOBUTYRIC ACID
L-Valine, 3-mercapto-
H-Pen-OH
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