Lifitegrast sodium
Modify Date: 2024-01-16 17:26:46
Lifitegrast sodium structure
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Common Name | Lifitegrast sodium | ||
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| CAS Number | 1119276-80-0 | Molecular Weight | 637.46300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H23Cl2N2NaO7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lifitegrast sodiumLifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease[1]. |
| Name | sodium,(2S)-2-[[2-(1-benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoate |
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| Synonym | More Synonyms |
| Description | Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease[1]. |
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| Related Catalog | |
| Target |
αLβ2 |
| In Vitro | Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses[1]. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM[1]. |
| In Vivo | Lifitegrast has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior[2]. |
| References |
| Molecular Formula | C29H23Cl2N2NaO7S |
|---|---|
| Molecular Weight | 637.46300 |
| Exact Mass | 636.05000 |
| PSA | 148.69000 |
| LogP | 6.23330 |
| Lifitegrast sodium |
| UNII-QG18FLP1KP |
| SAR-1118-023 |