Triethylenetetramine

Modify Date: 2026-06-29 19:06:04

Triethylenetetramine Structure
Triethylenetetramine structure
 Common Name Triethylenetetramine
CAS Number 112-24-3 Molecular Weight 146.234
Density 1.0±0.1 g/cm3 Boiling Point 266.5±0.0 °C at 760 mmHg
Molecular Formula C6H18N4 Melting Point 12 °C(lit.)
MSDS Chinese USA Flash Point 143.3±0.0 °C
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2,2,2-tetramine
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.0±0.1 g/cm3
Boiling Point 266.5±0.0 °C at 760 mmHg
Melting Point 12 °C(lit.)
Molecular Formula C6H18N4
Molecular Weight 146.234
Flash Point 143.3±0.0 °C
Exact Mass 146.153152
PSA 76.10000
LogP -2.18
Vapour density ~5 (vs air)
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.490
InChIKey VILCJCGEZXAXTO-UHFFFAOYSA-N
SMILES NCCNCCNCCN
Stability Syable. Incompatible with strong oxidizing agents, strong acids.
Water Solubility SOLUBLE
Freezing Point 12℃

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YE6650000
CHEMICAL NAME :
Triethylenetetramine
CAS REGISTRY NUMBER :
112-24-3
BEILSTEIN REFERENCE NO. :
0605448
LAST UPDATED :
199710
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C6-H18-N4
MOLECULAR WEIGHT :
146.28
WISWESSER LINE NOTATION :
Z2M2M2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
468 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
805 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
9130 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
17430 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
8715 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - homeostasis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
3667 mg/kg
SEX/DURATION :
female 10-56 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,31,1994 *** REVIEWS *** TOXICOLOGY REVIEW JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968- Volume(issue)/page/year: 15,808,1973 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 2 ppm (12 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82037 No. of Facilities: 1982 (estimated) No. of Industries: 37 No. of Occupations: 44 No. of Employees: 14389 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82037 No. of Facilities: 7057 (estimated) No. of Industries: 96 No. of Occupations: 88 No. of Employees: 165511 (estimated) No. of Female Employees: 20726 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H312-H314-H317-H412
Precautionary Statements P273-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive
Risk Phrases R21;R34;R43;R52/53
Safety Phrases S26-S36/37/39-S45-S61
RIDADR UN 2259 8/PG 2
WGK Germany 2
RTECS YE6650000
Packaging Group II
Hazard Class 8
HS Code 29212900

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2921290000
Summary 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles40

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents.

Chemistry 20(50) , 16602-12, (2014)

A structure-activity relationship study of a library of novel bifunctional Gd(III) complexes covalently linked to arylphosphonium cations is reported. Such complexes have been designed for potential a...

Chelating resin immobilizing carboxymethylated polyethyleneimine for selective solid-phase extraction of trace elements: Effect of the molecular weight of polyethyleneimine and its carboxymethylation rate.

Talanta 147 , 342-50, (2015)

The effect of the molecular weight of polyethyleneimine (PEI), defined as a compound having two or more ethyleneamine units, and of its carboxymethylation rate (CM/N), represented by the ratio of ion-...

Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

J. Med. Chem. 53 , 5511-22, (2010)

Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, phenols, and coumarins. Polyamines such as spermine, spermidine, and many synthetic congeners are described to constitute a novel c...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 203-950-6
Trientine
N,N'-Bis(2-aminoethyl)-1,2-ethanediamine
N,N'-Bis(2-aminoethyl)ethane-1,2-diamine
TRIETHYLENETETRAAMINE
Triethylenetetramine (TETA)
N,N-Di(2-Aminoethyl)Ethylenediamine
Triethylenetetramine
DEH 24 EPH 925
TETA
N,N'-Di(2-aminoethyl)ethylenediamine
1,8-diamino-3,6-diazaoctane
2,2,2-tetramine
N1,N1'-(Ethane-1,2-diyl)bis(ethane-1,2-diamine)
MFCD00008169
triethylene tetramine

 Triethylenetetramine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of 2,2,2-tetramine?
A: Boiling point of 2,2,2-tetramine is 266.5±0.0 °C at 760 mmHg.
Q: What are the upstream materials of 2,2,2-tetramine?
A: Related upstream materials(CAS) of 2,2,2-tetramine: 10526-69-9;540-61-4;107-06-2;50-00-0;74-90-8;107-15-3;151-56-4;111-40-0.
Q: What is the InChIKey of 2,2,2-tetramine?
A: InChIKey of 2,2,2-tetramine is VILCJCGEZXAXTO-UHFFFAOYSA-N.
Q: What is the melting point of 2,2,2-tetramine?
A: Melting point of 2,2,2-tetramine is 12 °C(lit.).
Q: What is the molecular weight of 2,2,2-tetramine?
A: Molecular weight of 2,2,2-tetramine is 146.234.
Q: What is the LogP of 2,2,2-tetramine?
A: LogP of 2,2,2-tetramine is -2.18.
Q: What is the SMILES notation of 2,2,2-tetramine?
A: SMILES notation of 2,2,2-tetramine is NCCNCCNCCN.
Q: What is the safety information for 2,2,2-tetramine?
A: Safety information for 2,2,2-tetramine: S26-S36/37/39-S45-S61.
Q: What are the downstream products of 2,2,2-tetramine?
A: Related downstream products(CAS) of 2,2,2-tetramine: 52667-88-6;141998-21-2;281193-14-4;295-14-7;24426-12-8;869-52-3;110-85-0;280-57-9;294-90-6;140-31-8.
Q: What is the English name of 2,2,2-tetramine?
A: The English name of 2,2,2-tetramine is 2,2,2-tetramine.

 Triethylenetetraminefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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