Tetramethylpyrazine

Modify Date: 2024-01-02 22:30:26

Tetramethylpyrazine structure	Common Name	Tetramethylpyrazine
	CAS Number	1124-11-4	Molecular Weight	136.19
	Density	1.0±0.1 g/cm3	Boiling Point	192.7±35.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₂N₂	Melting Point	77-80 °C(lit.)
	MSDS	Chinese USA	Flash Point	71.6±17.6 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Tetramethylpyrazine

Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].

Name	Tetramethylpyrazine
Synonym	More Synonyms

Description	Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vitro	Tetramethylpyrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Tetramethylpyrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury[1].
References	[1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638. [2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6. [3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201.

Density	1.0±0.1 g/cm3
Boiling Point	192.7±35.0 °C at 760 mmHg
Melting Point	77-80 °C(lit.)
Molecular Formula	C₈H₁₂N₂
Molecular Weight	136.19
Flash Point	71.6±17.6 °C
Exact Mass	136.100052
PSA	25.78000
LogP	1.56
Vapour Pressure	0.7±0.4 mmHg at 25°C
Index of Refraction	1.504
Stability	Stable. Incompatible with strong acids, strong oxidizing agents.

Tetramethylpyrazine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ3905000

CHEMICAL NAME :: Pyrazine, tetramethyl-

CAS REGISTRY NUMBER :: 1124-11-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H12-N2

MOLECULAR WEIGHT :: 136.22

WISWESSER LINE NOTATION :: T6N DNJ B1 C1 E1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1910 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,249,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJCREE International Journal of Crude Drug Research. (Swets & Zeitlinger B.V., POB 825, 2160 SZ Lisse, Netherlands) V.20- 1982- Volume(issue)/page/year: 23,119,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 239 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 4,319,1978

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ3905000
HS Code	29339990

Precursor 8
CAS#:513-86-0 Acetoin CAS#:17117-97-4 (E,E)-butane-2,... CAS#:27023-19-4 2,5-dichloro-3,... CAS#:75-24-1 trimethylaluminum
CAS#:513-85-9 (2R,3R)-(-)-2,3... CAS#:6628-81-5 Acetamide,N-(1-... CAS#:56-84-8 L-Aspartic acid CAS#:108-24-7 Ethanoic anhydride
DownStream 9
CAS#:107209-24-5 Pyrazine, trime... CAS#:22978-83-2 Pyrazine, tetra... CAS#:22978-84-3 Pyrazine,2,3,5,... CAS#:186534-01-0 3,5,6-TRIMETHYL...
CAS#:184826-44-6 2,3,5-trimethyl... CAS#:75907-74-3 (3,5,6-Trimethy... CAS#:186534-02-1 3,5,6-TriMethyl... CAS#:892396-47-3 2,3,5-trimethyl...
CAS#:79074-45-6 2-(bromomethyl)...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Characterization of Volatile Flavor Compounds in Chinese Rice Wine Fermented from Enzymatic Extruded Rice.

J. Food Sci. 80 , C1476-89, (2015)

Enzymatic extrusion, instead of traditional steam cooking, to treat rice is an efficient and alternative pretreatment for Chinese rice wine fermentation. In order to determine the formation of volatil...

Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.

Pharmazie 69(7) , 532-6, (2014)

The pregnane X receptor (PXR) is a key regulator of CYP3A4, which is involved in catalyzing the metabolic conversion of a number of endogenous substrates. In this study, we screened 22 compounds isola...

Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.

Bioorg. Med. Chem. 16 , 8868-74, (2008)

Ischemic stroke results from brain blood vessel blockage by thrombus, and produces neuronal cell damage and death. While thrombolytic therapy with tPA has achieved some success in clinic, the strategy...

Pyrazine, 2,3,5,6-tetramethyl-

MFCD00006146

Chuanxingzine

Ligustrazine

2,3,5,6-Tetramethylpyrazine

EINECS 214-391-2

2,3,5,6,-Tetramethyl-1,4-pyrazine

PPyrazine, tetramethyl-

Tetramethyl-1,4-diazine

Tetramethylpyrazine

2,3,5,6-TETRA METHYL PYRAZINE

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tetramethylpyrazine
Price: ￥228.0/20mg ￥128.0/25g ￥358.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Tetramethylpyrazine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tetramethylpyrazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tetramethylpyrazine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Tetramethylpyrazine suppliers

Price: ￥36/5g

Reference only. check more Tetramethylpyrazine price

Tetramethylpyrazine

Use of Tetramethylpyrazine

Names