Galanthamine-d6

Modify Date: 2024-01-10 14:02:52

Galanthamine-d6 structure	Common Name	Galanthamine-d6
	CAS Number	1128109-00-1	Molecular Weight	287.35354
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₁NO₃	Melting Point	121-122°C
	MSDS	N/A	Flash Point	N/A

Use of Galanthamine-d6

Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

Name	Galanthamine-O-(methyl-d3)-N-(methyl-d3)

Description	Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86. [3]. Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43. [4]. Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51.

Melting Point	121-122°C
Molecular Formula	C₁₇H₂₁NO₃
Molecular Weight	287.35354
Storage condition	Hygroscopic, -20?C Freezer, Under Inert Atmosphere

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