N,N-Bis(carboxymethyl)-L-lysine

Modify Date: 2024-01-02 18:47:01

N,N-Bis(carboxymethyl)-L-lysine Structure
N,N-Bis(carboxymethyl)-L-lysine structure
 Common Name N,N-Bis(carboxymethyl)-L-lysine
CAS Number 113231-05-3 Molecular Weight 262.26
Density 1.4±0.1 g/cm3 Boiling Point 537.8±50.0 °C at 760 mmHg
Molecular Formula C10H18N2O6 Melting Point >208°C
MSDS N/A Flash Point 279.0±30.1 °C

 Use of N,N-Bis(carboxymethyl)-L-lysine


Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].

 Names

Name (S)-N-(5-AMino-1-carboxypentyl)iMinodiacetic acid hydrate
Synonym More Synonyms

 N,N-Bis(carboxymethyl)-L-lysine Biological Activity

Description Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].
Related Catalog
References

[1]. Pydi SP, et al. Amino acid derivatives as bitter taste receptor (T2R) blockers. J Biol Chem. 2014;289(36):25054-25066.  

[2]. Sidhu C, et al. Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem. 2017;426(1-2):129-136.  

[3]. Masamoto M, et al. Yoshida R. Effects of bitter receptor antagonists on behavioral lick responses of mice. Neurosci Lett. 2020;730:135041.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 537.8±50.0 °C at 760 mmHg
Melting Point >208°C
Molecular Formula C10H18N2O6
Molecular Weight 262.26
Flash Point 279.0±30.1 °C
Exact Mass 262.116486
PSA 141.16000
LogP -1.77
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.552
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Stability Moisture Sensitive

 Safety Information

Hazard Codes Xi
WGK Germany 3
HS Code 2922509090

 Synthetic Route

N6-Carbobenzyloxy-N2,N2-bis(carboxymethyl)-L-lysine structure

N6-Carbobenzylo...

CAS#:113231-04-2

~77%

N,N-Bis(carboxymethyl)-L-lysine Structure

N,N-Bis(carboxy...

CAS#:113231-05-3

Literature: Lin, Yu-Chung; Liang, Ming-Ren; Lin, Yu-Chen; Chen, Chao-Tsen Chemistry - A European Journal, 2011 , vol. 17, # 46 p. 13059 - 13067
N-(5-Amino-1-carboxypentyl)iminodiacetic Acid Tri-t-butyl Ester structure

N-(5-Amino-1-ca...

CAS#:205379-08-4

~%

N,N-Bis(carboxymethyl)-L-lysine Structure

N,N-Bis(carboxy...

CAS#:113231-05-3

Literature: Journal of the American Chemical Society, , vol. 127, # 29 p. 10205 - 10215
N6-Cbz-L-Lysine structure

N6-Cbz-L-Lysine

CAS#:1155-64-2

~%

N,N-Bis(carboxymethyl)-L-lysine Structure

N,N-Bis(carboxy...

CAS#:113231-05-3

Literature: Analytical Chemistry, , vol. 78, # 17 p. 6065 - 6073
N2,N2-Bis[2-(1,1-dimethylethoxy)-2-oxoethyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine 1,1-Dimethylethyl Ester structure

N2,N2-Bis[2-(1,...

CAS#:205379-07-3

~%

N,N-Bis(carboxymethyl)-L-lysine Structure

N,N-Bis(carboxy...

CAS#:113231-05-3

Literature: Journal of the American Chemical Society, , vol. 128, # 7 p. 2365 - 2372

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

BIS-BOC-L-CYSTINE
MFCD00237437
BOC-L-CYSTINE extrapure
N,N-Bis(carboxymethyl)-L-lysine
N N-BOC-L-CYSTEINE
L-Lysine, N,N-bis(carboxymethyl)-
N,N'-di-Boc-cystine
N,N'-Bis-Boc-cystine
BOC-L-CYSTINE
N,N-di-Boc-L-cystine
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