Caryophyllene oxide

Modify Date: 2026-07-05 00:09:03

Caryophyllene oxide structure	Common Name	Caryophyllene oxide
	CAS Number	1139-30-6	Molecular Weight	220.350
	Density	1.0±0.1 g/cm3	Boiling Point	279.7±19.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₄O	Melting Point	62-63ºC(lit.)
	MSDS	Chinese USA	Flash Point	119.7±19.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of Caryophyllene oxide

Caryophyllene oxide, isolated from from Annona squamosa L. bark., possesses analgesic and anti-inflammatory activity[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	(-)-Caryophyllene oxide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Caryophyllene oxide, isolated from from Annona squamosa L. bark., possesses analgesic and anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Chavan MJ, et al. Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine. 2010 Feb;17(2):149-51.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0±0.1 g/cm3
Boiling Point	279.7±19.0 °C at 760 mmHg
Melting Point	62-63ºC(lit.)
Molecular Formula	C₁₅H₂₄O
Molecular Weight	220.350
Flash Point	119.7±19.5 °C
Exact Mass	220.182709
PSA	12.53000
LogP	4.57
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.507
InChIKey	NVEQFIOZRFFVFW-RGCMKSIDSA-N
SMILES	C=C1CCC2OC2(C)CCC2C1CC2(C)C

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Caryophyllene oxide MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP5530000

CHEMICAL NAME :: 5-Oxatricyclo(8.2.0.0(sup 4,6))dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

CAS REGISTRY NUMBER :: 1139-30-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H24-O

MOLECULAR WEIGHT :: 220.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	RP5530000
HS Code	29109000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

trans-Caryophyllene

CAS#:87-44-5

Caryophyllene oxide

CAS#:1139-30-6

N/A

CAS#:103475-43-0

Learn More

Literature: Helvetica Chimica Acta, , vol. 77, # 1 p. 36 - 40

trans-Caryophyllene

CAS#:87-44-5

Caryophyllene oxide

CAS#:1139-30-6

Learn More

Literature: Helvetica Chimica Acta, , vol. 66, # 7 p. 2223 - 2235

Perbenzoic acid

CAS#:93-59-4

trans-Caryophyllene

CAS#:87-44-5

Caryophyllene oxide

CAS#:1139-30-6

Learn More

Literature: Chemische Berichte, , vol. 80, p. 56,62 Journal of the Chemical Society, , p. 537,539

perphthalic acid

CAS#:2311-91-3

trans-Caryophyllene

CAS#:87-44-5

Caryophyllene oxide

CAS#:1139-30-6

Learn More

Literature: Journal of the Chemical Society, , p. 4336,4339

trans-Caryophyllene

CAS#:87-44-5

~53%

Caryophyllene oxide

CAS#:1139-30-6

(2R,5R,6R)-2,12...

CAS#:60444-80-6

(1R,4R,6R,9S,10...

CAS#:60479-10-9

Learn More

Literature: Bulletin de la Societe Chimique de France, , vol. 132, # 8 p. 836 - 842

trans-Caryophyllene

CAS#:87-44-5

(1R,4R,5R,9S,11...

CAS#:118122-82-0

(1R,4R,5R,9S,11...

CAS#:108525-13-9

14-hydroxycaryo...

CAS#:73510-14-2

Detail Learn More

Literature: Phytochemistry (Elsevier), , vol. 29, # 1 p. 115 - 120

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:87-44-5 trans-Caryophyllene CAS#:93-59-4 Perbenzoic acid CAS#:2311-91-3 perphthalic acid
DownStream 1
CAS#:32214-91-8 caryophyllene a...

This table lists relevant public references with title, journal and publication metadata for this compound.

Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.

J. Nat. Prod. 74 , 559-66, (2011)

In a survey of plants from Ecuador with antiprotozoal activity, Cupania cinerea was found to show significant in vitro activity against the Plasmodium falciparum K1 strain and Trypanosoma brucei rhode...

Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives.

J. Nat. Prod. 69 , 1429-34, (2006)

Microbial transformation of the sesquiterpene (-)-caryophyllene oxide (1) [(1R,4R,5R,9S)-4,5-epoxycaryophyllan-8(13)-ene] by a number of fungi, using a standard two-stage fermentation technique, has a...

H.M.R. Hoffmann, U. Vogt

Synlett , 581, (1990)

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Cytotoxicity against human HL cells assessed as cell viability at 50 uM after 72 hrs ...
Source: ChEMBL
Target: HL
External Id: CHEMBL4135472

Name: Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells assessed...
Source: ChEMBL
Target: Chlamydia pneumoniae
External Id: CHEMBL4135473

Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788

Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Total 137, Current Page 1 of 14

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(1R,4R,6R,10S)-4,12,12-trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane

(-)-b-Caryophyllene oxide

6,7-Epoxy-3(15)-caryophyllene

(−)-Caryophyllene oxide

4b,5a-Epoxycaryophyllene

(-)-b-Caryophyllene epoxide

(1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.0]dodecane

(-)-Epoxydihydrocaryophyllene

(-)-caryophyllene oxide

b-Caryophyllene oxide

Caryophyllene 4b,5a-oxide

β-Caryophyllene oxide

EINECS 214-519-7

MFCD00134216

b-Caryophyllene epoxide

trans-caryophyllene oxide

caryophyllene oxide

(−)-Epoxycaryophyllene

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of (-)-Caryophyllene oxide?

A: InChIKey of (-)-Caryophyllene oxide is NVEQFIOZRFFVFW-RGCMKSIDSA-N.

Q: What is the CAS number of (-)-Caryophyllene oxide?

A: CAS number of (-)-Caryophyllene oxide is 1139-30-6.

Q: What is the English name of (-)-Caryophyllene oxide?

A: The English name of (-)-Caryophyllene oxide is (-)-Caryophyllene oxide.

Q: What is the melting point of (-)-Caryophyllene oxide?

A: Melting point of (-)-Caryophyllene oxide is 62-63ºC(lit.).

Q: What is the boiling point of (-)-Caryophyllene oxide?

A: Boiling point of (-)-Caryophyllene oxide is 279.7±19.0 °C at 760 mmHg.

Q: What is the safety information for (-)-Caryophyllene oxide?

A: Safety information for (-)-Caryophyllene oxide: 26.

Q: What are the uses of (-)-Caryophyllene oxide?

A: Main uses of (-)-Caryophyllene oxide: Caryophyllene oxide, isolated from from Annona squamosa L. bark., possesses analgesic and anti-inflammatory activity[1].

Q: What is the SMILES notation of (-)-Caryophyllene oxide?

A: SMILES notation of (-)-Caryophyllene oxide is C=C1CCC2OC2(C)CCC2C1CC2(C)C.

Q: What is the LogP of (-)-Caryophyllene oxide?

A: LogP of (-)-Caryophyllene oxide is 4.57.

Q: What are the downstream products of (-)-Caryophyllene oxide?

A: Related downstream products(CAS) of (-)-Caryophyllene oxide: 32214-91-8.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

Dayang Chem (Hangzhou) Co., Ltd.

naturewill

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Caryophyllene oxide
Price: Check
Purity: 90.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Caryophyllene oxide
Price: ￥Inquiry/5mg
Purity: 93.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: b-Caryophyllene oxide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: Caryophyllene oxide
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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