trans-Caryophyllene

Modify Date: 2026-07-01 17:11:54

trans-Caryophyllene structure	Common Name	trans-Caryophyllene
	CAS Number	87-44-5	Molecular Weight	204.351
	Density	0.9±0.1 g/cm3	Boiling Point	268.4±10.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	104.9±13.8 °C

Use of trans-Caryophyllene

β-Caryophyllene is a CB2 receptor agonist.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	(-)-β-caryophyllene
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	β-Caryophyllene is a CB2 receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Cancer Research Areas >> Infection Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides
Target	CB2 receptor[1]
In Vitro	Among the tested cancer cells, β-Caryophyllene demonstrates selective anti-proliferative effect against three cancer cell lines, namely HCT 116 (colon cancer, IC50=19 μM), PANC-1 (pancreatic cancer, IC50=27 μM), and HT29 (colon cancer, IC50=63 μM) cells, whereas β-Caryophyllene exhibits either moderate or poor cytotoxic effects against ME-180, PC3, K562 and MCF-7. Results show that β-Caryophyllene possesses higher selectivity towards the colorectal cancer cells (HCT 116), with selectivity index (SI)=27.9, followed by PANC-1 and HT 29 cells with SI=19.6 and 8, respectively. The apoptotic index estimated for β-Caryophyllene treatment on HCT 116 cells after 24 h treatment is 64±0.04. β-Caryophyllene at 10 μM concentration, causes significant nuclei condensation after 6 h of treatment. β-caryophyllene exhibits a dose and time-dependent inhibitory effect on the motility of HCT 116 cells[2].
In Vivo	Treatment with β-Caryophyllene at different doses does not show any effects on swimming speed during the test. Oral treatment with β-Caryophyllene ameliorates the rise in β-amyloid deposition in the transgenic mice in a roughly dose-dependent manner, and the two higher doses exhibit almost equal effects in modifying the β-amyloid burden. The number of activated astroglial cells is higher in vehicle-treated mouse brains than in β-Caryophyllene-treated mouse brains with different doses. β-Caryophyllene is effective at reducing the enhancement of the COX-2 protein level found in vehicle-treated APP/PS1 mice[1]. Animals treated with β-Caryophyllene display higher values of object recognition index than their vehicle-treated counterparts [t(14)=4.204, P<0.05]. The total time spent in object exploration during the test trial is not significantly different between β-Caryophyllene-treated and vehicle-treated animals (t(14)=0.5874, P>0.05). Treatment with β-Caryophyllene does not significantly alter these seizure-induced neurochemical changes[3].
Cell Assay	Panel of human cancer cells such as, pancreatic (PANC-1), colorectal (HCT-116 and HT-29), invasive squamous cell carcinoma (ME-180), leukemia (K562), hormone sensitive and invasive breast cancer cell line (MCF-7), and prostatic (PC3) adenocarcinoma cell lines are used. Cells are incubated in a humidified CO2 incubator at 37°C supplied with 5% CO2. Inhibitory effect of β-Caryophyllene on proliferation of the cell lines is tested using the MTT assay. The selectivity index (SI) for the cytotoxicity of β-Caryophyllene is calculated using the ratio of IC50 of β-Caryophyllene on a normal cell line (NIH-3T3) to the IC50 of β-Caryophyllene on cancer cell lines[2].
Animal Admin	Male double transgenic APP/PS1 mice and wild-type littermates are used. The mice are group housed (3 to 5 animals/cage) with a 12:12-hour light/dark cycle and ad libitum access to food and water. In this experiment, animals are orally treated by gavage with 16, 48, or 144 mg/kg of β-Caryophyllene every morning for 10 weeks starting at the age of 7 months. All vehicle solutions are used for the respective control animal treatments and the Morris water maze test is performed[1].
References	[1]. Cheng Y, et al. β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacology. 2014;94(1-2):1-12. [2]. Dahham SS, et al. The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllenefrom the Essential Oil of Aquilaria crassna. Molecules. 2015 Jun 26;20(7):11808-29. [3]. de Oliveira CC, et al. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016 Mar;56:26-31.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	268.4±10.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₄
Molecular Weight	204.351
Flash Point	104.9±13.8 °C
Exact Mass	204.187805
LogP	6.78
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.495
InChIKey	NPNUFJAVOOONJE-QWAJQTJBSA-N
SMILES	C=C1CCC=C(C)CCC2C1CC2(C)C

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

trans-Caryophyllene MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DT8400000

CHEMICAL NAME :: Bicyclo(7.2.0)undec-4-ene, 8-methylene-4,11,11-trimethyl-, (E)-(1R,9S)-(-)-

CAS REGISTRY NUMBER :: 87-44-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H24

MOLECULAR WEIGHT :: 204.39

WISWESSER LINE NOTATION :: L49 EY HUTJ B1 B1 EU1 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1059,1973 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >48 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pulmonary emboli

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,78,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7407 No. of Facilities: 3144 (estimated) No. of Industries: 10 No. of Occupations: 18 No. of Employees: 44746 (estimated) No. of Female Employees: 27262 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	DT8400000
HS Code	2902199090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

(1S,9R)-6,10,10...

CAS#:60362-44-9

Methyltriphenyl...

CAS#:1779-49-3

~80%

trans-Caryophyllene

CAS#:87-44-5

Learn More

Literature: Larionov, Oleg V.; Corey Journal of the American Chemical Society, 2008 , vol. 130, # 10 p. 2954 - 2955

4,5-epithiocary...

CAS#:65563-95-3

~10%

trans-Caryophyllene

CAS#:87-44-5

Learn More

Literature: Peppard, Terence L.; Sharpe, F. Richard; Elvidge, John A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 311 - 313

β-caryophyllene...

CAS#:60594-22-1

trans-Caryophyllene

CAS#:87-44-5

N/A

CAS#:122571-86-2

4,5-dihydrocary...

CAS#:86834-01-7

Detail Learn More

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 25, # 1.2 p. 109 - 118 Zhurnal Organicheskoi Khimii, , vol. 25, # 1 p. 122 - 132

β-caryophyllene...

CAS#:60594-22-1

trans-Caryophyllene

CAS#:87-44-5

(1R,3Z,9S)-4,11...

CAS#:136296-35-0

10,10-dimethyl-...

CAS#:136296-38-3

Learn More

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 26, # 10.2 p. 1839 - 1852 Zhurnal Organicheskoi Khimii, , vol. 26, # 10 p. 2129 - 2145

β-caryophyllene...

CAS#:60594-22-1

trans-Caryophyllene

CAS#:87-44-5

isocaryophyllene

CAS#:118-65-0

(1R,3Z,9S)-4,11...

CAS#:136296-35-0

Detail Learn More

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 26, # 10.2 p. 1839 - 1852 Zhurnal Organicheskoi Khimii, , vol. 26, # 10 p. 2129 - 2145

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:60362-44-9 (1S,9R)-6,10,10... CAS#:1779-49-3 Methyltriphenyl... CAS#:60594-22-1 β-caryophyllene...
DownStream 10
CAS#:58404-89-0 (1alpha,2alpha,... CAS#:469-92-1 (-)-CLOVENE CAS#:31887-51-1 (1R,2S,7S,9R)-2... CAS#:4545-68-0 (-)-ALPHA-[1-(D...
CAS#:6753-98-6 Alpha-caryophyllene CAS#:95-13-6 Indene CAS#:86-73-7 9H FLUORENE CAS#:28834-17-5 4,11,11-trimeth...
CAS#:129-00-0 Pyrene CAS#:597-43-3 2,2,-Dimethylsu...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2902199090
Summary	2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Chemical composition, antioxidant, and antimicrobial activities of essential oil from pine needle (Cedrus deodara).

J. Food Sci. 77(7) , C824-9, (2012)

The chemical composition of essential oil from pine needles (Cedrus deodara) was determined, and its antioxidant and antimicrobial activities were evaluated. Twenty-three components, representing 95.7...

Chemical diversity among the essential oils of wild populations of Stachys lavandulifolia VAHL (Lamiaceae) from Iran.

Chem. Biodivers. 10(2) , 262-73, (2013)

The variation of the essential-oil composition among ten wild populations of Stachys lavandulifolia VAHL (Lamiaceae), collected from different geographical regions of Iran, was assessed by GC-FID and ...

Chemical composition and biological activities of soldiers of the Brazilian termite species, Nasutitermes macrocephalus (Isoptera: Natutitermitinae).

Nat. Prod. Commun. 8(1) , 69-74, (2013)

The defensive secretion of the frontal gland from termite soldiers is a mixture of monoterpenes, sesquiterpenes and diterpenes, the latter being the most representative. Analyses of the dichloromethan...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

Total 245, Current Page 1 of 25

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

[1R-(1R*,4E,9S*)]-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene

trans-Caryophyllene

β-caryophyllene

MFCD00075925

(-)-trans-Caryophyllene

(1R,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene

Caryophyllene (VAN)

(1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene

EINECS 201-746-1

l-Caryophyllene

(-)-beta-caryophyllene

(-)-Caryophyllene

β-(E)-Caryophyllene

Caryophyllene

(E)-Caryophyllene

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of (-)-β-caryophyllene?

A: The English name of (-)-β-caryophyllene is (-)-β-caryophyllene.

Q: What is the molecular weight of (-)-β-caryophyllene?

A: Molecular weight of (-)-β-caryophyllene is 204.351.

Q: What are the upstream materials of (-)-β-caryophyllene?

A: Related upstream materials(CAS) of (-)-β-caryophyllene: 60362-44-9;1779-49-3;60594-22-1.

Q: What English synonyms does (-)-β-caryophyllene have?

A: English synonyms of (-)-β-caryophyllene: [1R-(1R*,4E,9S*)]-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene, trans-Caryophyllene, β-caryophyllene, MFCD00075925, (-)-trans-Caryophyllene, (1R,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene, Caryophyllene (VAN), (1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene, EINECS 201-746-1, l-Caryophyllene, (-)-beta-caryophyllene, (-)-Caryophyllene, β-(E)-Caryophyllene, Caryophyllene, (E)-Caryophyllene.

Q: What is the CAS number of (-)-β-caryophyllene?

A: CAS number of (-)-β-caryophyllene is 87-44-5.

Q: What is the safety information for (-)-β-caryophyllene?

A: Safety information for (-)-β-caryophyllene: S26-S36.

Q: What are the downstream products of (-)-β-caryophyllene?

A: Related downstream products(CAS) of (-)-β-caryophyllene: 58404-89-0;469-92-1;31887-51-1;4545-68-0;6753-98-6;95-13-6;86-73-7;28834-17-5;129-00-0;597-43-3.

Q: What is the molecular formula of (-)-β-caryophyllene?

A: Molecular formula of (-)-β-caryophyllene is C15H24.

Q: What is the SMILES notation of (-)-β-caryophyllene?

A: SMILES notation of (-)-β-caryophyllene is C=C1CCC=C(C)CCC2C1CC2(C)C.

Q: What is the LogP of (-)-β-caryophyllene?

A: LogP of (-)-β-caryophyllene is 6.78.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: trans-Caryophyllene
Price: Check
Purity: 80.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: trans-Caryophyllene
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Caryophyllene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM-- BETA-CARYOPHYLLENE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: trans-Caryophyllene
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

trans-Caryophyllene suppliers

Price: $55/10mM*1mLinDMSO

Reference only. check more trans-Caryophyllene price

trans-Caryophyllene

Use of trans-Caryophyllene

Names