Fascaplysin (chloride)|CDK4 inhibitor structure
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Common Name | Fascaplysin (chloride)|CDK4 inhibitor | ||
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CAS Number | 114719-57-2 | Molecular Weight | 306.75 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H11ClN2O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Fascaplysin (chloride)|CDK4 inhibitorFascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2]. |
Name | Fascaplysin |
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Synonym | More Synonyms |
Description | Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2]. |
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Related Catalog | |
In Vitro | Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2]. Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2]. .Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2]. |
In Vivo | Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2] |
References |
Molecular Formula | C18H11ClN2O |
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Molecular Weight | 306.75 |
Exact Mass | 306.05600 |
PSA | 36.74000 |
LogP | 0.14620 |
Hazard Codes | Xi: Irritant; |
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Risk Phrases | R36/37/38 |
Safety Phrases | S26 |
fascaplysine |
GNF-PF-1458 |