Bromo-PEG3-C2-phosphonic acid

Modify Date: 2024-01-02 11:28:47

Bromo-PEG3-C2-phosphonic acid Structure
Bromo-PEG3-C2-phosphonic acid structure
Common Name Bromo-PEG3-C2-phosphonic acid
CAS Number 1148026-99-6 Molecular Weight 321.103
Density 1.5±0.1 g/cm3 Boiling Point 458.1±55.0 °C at 760 mmHg
Molecular Formula C8H18BrO6P Melting Point N/A
MSDS N/A Flash Point 230.9±31.5 °C

 Use of Bromo-PEG3-C2-phosphonic acid


Bromo-PEG3-C2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (2-{2-[2-(2-Bromoethoxy)ethoxy]ethoxy}ethyl)phosphonic acid
Synonym More Synonyms

 Bromo-PEG3-C2-phosphonic acid Biological Activity

Description Bromo-PEG3-C2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 458.1±55.0 °C at 760 mmHg
Molecular Formula C8H18BrO6P
Molecular Weight 321.103
Flash Point 230.9±31.5 °C
Exact Mass 320.002441
LogP -1.75
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.497

 Synonyms

MFCD11982881
Phosphonic acid, [2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]-
(2-{2-[2-(2-Bromoethoxy)ethoxy]ethoxy}ethyl)phosphonic acid