DC07090 dihydrochloride
Modify Date: 2024-04-06 17:59:12
DC07090 dihydrochloride structure
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Common Name | DC07090 dihydrochloride | ||
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| CAS Number | 1158264-37-9 | Molecular Weight | 375.25 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16Cl2N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DC07090 dihydrochlorideDC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1]. |
| Name | DC07090 dihydrochloride |
|---|
| Description | DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1]. |
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| Related Catalog | |
| Target |
IC50: 21.72 μM (EV71 3C protease)[1]. Ki: 23.29 μM (EV71 3C protease)[1]. EC50: 27.76 μM (coxsackievirus A16)[1] |
| In Vitro | DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM[1]. |
| References |
| Molecular Formula | C18H16Cl2N4O |
|---|---|
| Molecular Weight | 375.25 |