succinylsulfathiazole

Modify Date: 2025-08-29 19:05:37

succinylsulfathiazole Structure
succinylsulfathiazole structure
 Common Name succinylsulfathiazole
CAS Number 116-43-8 Molecular Weight 355.389
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C13H13N3O5S2 Melting Point 187 - 193ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of succinylsulfathiazole


Succinylsulfathiazole is a sulfonamide, it is an ultra long acting drug.

 Names

Name 4'-(2-Thiazolylsulfamoyl)succinanilic acid
Synonym More Synonyms

 succinylsulfathiazole Biological Activity

Description Succinylsulfathiazole is a sulfonamide, it is an ultra long acting drug.
Related Catalog

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Melting Point 187 - 193ºC
Molecular Formula C13H13N3O5S2
Molecular Weight 355.389
Exact Mass 355.029663
PSA 162.08000
LogP 0.68
Index of Refraction 1.679
InChIKey SKVLYVHULOWXTD-UHFFFAOYSA-N
SMILES O=C(O)CCC(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WM4767000
CHEMICAL NAME :
Succinanilic acid, 4'-(2-thiazolylsulfamoyl)-
CAS REGISTRY NUMBER :
116-43-8
BEILSTEIN REFERENCE NO. :
0349989
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C13-H13-N3-O5-S2
MOLECULAR WEIGHT :
355.41
WISWESSER LINE NOTATION :
T5N CSJ BMSWR DMV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,231,1942
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 7,151,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81640 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 230 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R42/43
Safety Phrases S22-S36/37-S45
RIDADR 3249
WGK Germany 3
RTECS WM4767000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2935009090

 Synthetic Route

Succinic anhydride structure

Succinic anhydride

CAS#:108-30-5

Sulfathiazole structure

Sulfathiazole

CAS#:72-14-0

~71%

succinylsulfathiazole Structure

succinylsulfath...

CAS#:116-43-8

Literature: Burdulene; Stumbryavichyute; Talaikite; Vladyko; Boreko; Korobchenko Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 9 p. 471 - 473
N,N-succinyl-sulfanilic acid thiazol-2-ylamide structure

N,N-succinyl-su...

CAS#:36340-57-5

~%

succinylsulfathiazole Structure

succinylsulfath...

CAS#:116-43-8

Literature: Journal of the American Chemical Society, , vol. 64, p. 1572,1573, 1574 Journal of the Chemical Society, , p. 751
Sulfathiazole structure

Sulfathiazole

CAS#:72-14-0

~%

succinylsulfathiazole Structure

succinylsulfath...

CAS#:116-43-8

Literature: Journal of the American Chemical Society, , vol. 64, p. 1572,1573, 1574
2-Aminothiazole structure

2-Aminothiazole

CAS#:96-50-4

N-(4-chlorosulfonyl-phenyl)-succinamic acid structure

N-(4-chlorosulf...

CAS#:5694-39-3

~%

succinylsulfathiazole Structure

succinylsulfath...

CAS#:116-43-8

Literature: Journal of the American Chemical Society, , vol. 64, p. 1572,1573, 1574
Succinic acid structure

Succinic acid

CAS#:110-15-6

Sulfathiazole structure

Sulfathiazole

CAS#:72-14-0

~%

succinylsulfathiazole Structure

succinylsulfath...

CAS#:116-43-8

Literature: Journal of the American Chemical Society, , vol. 64, p. 1572,1573, 1574

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles30

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Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie...

 succinylsulfathiazoleBioassay

View more

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
Name: qHTS for Inhibitors of TGF-b
Source: NCGC
Target: Smad3 [Homo sapiens]
External Id: SMAD3101
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 Synonyms

EINECS 204-141-0
MFCD00022437
succinylsulfathiazole
4-(Succinylamino)-N-(2-thiazolyl)benzenesulfonamide Hydrate
Succinylsulfathiazole Hydrate
4-(Succinylamino)-N-(2-thiazolyl)benzenesulfonamide
N1-(2-THIAZOLYL)-N4-SUCCINOYLSULFANILAMIDE
N4-Succinyl-N-(2-thiazolyl)sulfanilamide Hydrate
N4-Succinyl-N-(2-thiazolyl)sulfanilamide
4-oxo-4-[4-(1,3-thiazol-2-ylsulfamoyl)anilino]butanoic acid
p-2-Thiazolylsulfamoylsuccinanilic acid
4-Oxo-4-{[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]amino}butanoic acid
4-oxo-4-{4-[(1,3-thiazol-2-ylamino)sulfonyl]anilino}butanoic acid
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