L-LYSYL-D-PROLYL-L-THREONINE

Modify Date: 2024-01-29 12:55:53

L-LYSYL-D-PROLYL-L-THREONINE Structure
L-LYSYL-D-PROLYL-L-THREONINE structure
 Common Name L-LYSYL-D-PROLYL-L-THREONINE
CAS Number 117027-34-6 Molecular Weight 344.41
Density 1.288g/cm3 Boiling Point 691.3ºC at 760mmHg
Molecular Formula C15H28N4O5 Melting Point N/A
MSDS N/A Flash Point 371.9ºC

 Use of L-LYSYL-D-PROLYL-L-THREONINE


Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].

 Names

Name h-lys-d-pro-thr-oh
Synonym More Synonyms

 L-LYSYL-D-PROLYL-L-THREONINE Biological Activity

Description Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].
Related Catalog
Target

IL-1

In Vivo Lys-D-Pro-Thr (10 mg/kg; 腹腔给药; 持续 4 天) 抑制 fMLP (HY-P0224) 和 MMK-1 (HY-P1117) 对依托泊苷 (HY-13629) 诱导脱发的保护作用[1]。 Animal Model: 11-d-old rats[1] Dosage: 10 mg/kg Administration: IP; for 4 days Result: Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.
References

[1]. Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202.  

[2]. Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11.  

 Chemical & Physical Properties

Density 1.288g/cm3
Boiling Point 691.3ºC at 760mmHg
Molecular Formula C15H28N4O5
Molecular Weight 344.41
Flash Point 371.9ºC
Exact Mass 344.20600
PSA 158.98000
LogP 0.11330
Vapour Pressure 4.12E-22mmHg at 25°C
Index of Refraction 1.56

 Safety Information

Safety Phrases 22-24/25

 Synonyms

l-lysyl-d-prolyl-l-threonine
l-lys-d-pro-l-thr
lys-d-pro-thr
interleukin 1b antagonist
[D-Pro194]-IL-1 b (193-195) (human)
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