M 1145 TFA

Modify Date: 2024-01-09 18:50:07

M 1145 TFA Structure
M 1145 TFA structure
Common Name M 1145 TFA
CAS Number 1172089-00-7 Molecular Weight 2774.23
Density N/A Boiling Point N/A
Molecular Formula C128H205N37O32 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of M 1145 TFA


M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].

 Names

Name M1145

 M 1145 TFA Biological Activity

Description M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].
Related Catalog
In Vitro M1145 has an additive effect on the signal transduction of galanin, are concentrations of M1145 of 0.1 μM and higher all give a maximum transduction. Signal transduction was examined by assessing the ability to stimulate inositol phosphates (IP) production in CHO cells expressing GalR2. Treatment with M1145, which stimulates IP production with an EC50 of 38 nM[1].
References

[1]. Runesson J, Saar I, Lundström L, Järv J, Langel U. A novel GalR2-specific peptide agonist. Neuropeptides. 2009;43(3):187-192.

 Chemical & Physical Properties

Molecular Formula C128H205N37O32
Molecular Weight 2774.23
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