GW 583340 dihydrochloride
Modify Date: 2024-01-02 09:39:23
GW 583340 dihydrochloride structure
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Common Name | GW 583340 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1173023-85-2 | Molecular Weight | 671.03 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H27Cl3FN5O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GW 583340 dihydrochlorideGW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity[1][2][3]. |
| Name | GW583340 |
|---|---|
| Synonym | More Synonyms |
| Description | GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | GW 583340 dihydrochloride (5 μM) 降低 Mitoxantrone 抑制 ABCG2-482-R2 和 ABCG2-482-T7 细胞系的 IC50 值[1]。 GW 583340 dihydrochloride (2.5 和 7.5 μM，24 小时) 增加 SUM149 和 SUM190 细胞中 ROS 的积累，并诱导细胞凋亡[2]。 GW 583340 dihydrochloride (0-10 μM) 减少 SCCF1 细胞和 CatMC 细胞中的集落形成[2]。 |
| References |
| Molecular Formula | C28H27Cl3FN5O3S2 |
|---|---|
| Molecular Weight | 671.03 |
| Exact Mass | 669.060486 |
| GW583340 |
| GW583340 DIHYDROCHLORIDE |
| N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[2-({[2-(methylsulfonyl)ethyl]amino}methyl)-1,3-thiazol-4-yl]-4-quinazolinamine dihydrochloride |
| 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-, hydrochloride (1:2) |
| N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[2-({[2-(methylsulfonyl)ethyl]amino}methyl)-1,3-thiazol-4-yl]quinazolin-4-amine dihydrochloride |
| MFCD07370137 |
| 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride |