1,3-Dichloro-5,5-dimethylhydantoin

Modify Date: 2026-07-01 10:09:01

1,3-Dichloro-5,5-dimethylhydantoin Structure
1,3-Dichloro-5,5-dimethylhydantoin structure
 Common Name 1,3-Dichloro-5,5-dimethylhydantoin
CAS Number 118-52-5 Molecular Weight 197.019
Density 1.6±0.1 g/cm3 Boiling Point 214.7±23.0 °C at 760 mmHg
Molecular Formula C5H6Cl2N2O2 Melting Point 132-134 °C(lit.)
MSDS Chinese USA Flash Point 83.7±22.6 °C
Symbol GHS03 GHS05 GHS07 GHS08 GHS09
GHS03, GHS05, GHS07, GHS08, GHS09		 Signal Word Danger

Summary: 1,3-Dichloro-5,5-dimethylhydantoin, also known as 1,3-Dichloro-5,5-dimethylhydantoin, has a molecular formula of C5H6Cl2N2O2 and a molecular weight of 197.019. It is a white to grayish-white crystalline powder. CAS number: 118-52-5.主要用于杀菌和灭藻，能有效杀灭细菌、真菌、病毒及藻类。For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 1,3-Dichloro-5,5-dimethylhydantoin
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.6±0.1 g/cm3
Boiling Point 214.7±23.0 °C at 760 mmHg
Melting Point 132-134 °C(lit.)
Molecular Formula C5H6Cl2N2O2
Molecular Weight 197.019
Flash Point 83.7±22.6 °C
Exact Mass 195.980637
PSA 40.62000
LogP 1.36
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.572
InChIKey KEQGZUUPPQEDPF-UHFFFAOYSA-N
SMILES CC1(C)C(=O)N(Cl)C(=O)N1Cl
Water Solubility 0.21 g/100 mL (25 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU0700000
CHEMICAL NAME :
Hydantoin, 1,3-dichloro-5,5-dimethyl-
CAS REGISTRY NUMBER :
118-52-5
BEILSTEIN REFERENCE NO. :
0146013
LAST UPDATED :
199712
DATA ITEMS CITED :
37
MOLECULAR FORMULA :
C5-H6-Cl2-N2-O2
MOLECULAR WEIGHT :
197.03
WISWESSER LINE NOTATION :
T5NVNV EHJ AG CG E1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
542 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 gm/m3/1H
TOXIC EFFECTS :
Behavioral - tremor Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1520 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8784 mg/kg/28D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
634 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - rat Embryo
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 1,190,1981 *** REVIEWS *** ACGIH TLV-STEL 0.4 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.2 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.2 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,78,1971 OSHA PEL (Gen Indu):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993 OEL-BELGIUM:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.2 mg/m3 JAN 1993 OEL-FINLAND:TWA 0.2 mg/m3;STEL 0.6 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.2 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:10H TWA 0.2 mg/m3;STEL 0.4 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24100 No. of Facilities: 729 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 2224 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24100 No. of Facilities: 436 (estimated) No. of Industries: 9 No. of Occupations: 10 No. of Employees: 3502 (estimated) No. of Female Employees: 1780 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS03 GHS05 GHS07 GHS08 GHS09
GHS03, GHS05, GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H272-H302-H314-H334-H400
Supplemental HS Contact with acids liberates toxic gas.
Precautionary Statements P220-P261-P273-P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R8;R22;R34
Safety Phrases S26-S36-S45-S36/37/39-S17-S61
RIDADR UN 1479 5.1/PG 2
WGK Germany 3
RTECS MU0700000
Packaging Group II
Hazard Class 5.1
HS Code 29332100

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

5,5-Dimethylimidazolidine-2,4-dione structure

5,5-Dimethylimi...

CAS#:77-71-4

~86%

1,3-Dichloro-5,5-dimethylhydantoin Structure

1,3-Dichloro-5,...

CAS#:118-52-5

Learn More
Literature: Tetrahedron Letters, , vol. 50, # 6 p. 656 - 658
Sodium cyanide structure

Sodium cyanide

CAS#:143-33-9

Acetone structure

Acetone

CAS#:67-64-1

~%

1,3-Dichloro-5,5-dimethylhydantoin Structure

1,3-Dichloro-5,...

CAS#:118-52-5

Learn More
Literature: Anales de la Asociacion Quimica Argentina (1921-2001), , vol. 41, p. 153
2-cyanopropan-2-ylurea structure

2-cyanopropan-2...

CAS#:79662-84-3

~%

1,3-Dichloro-5,5-dimethylhydantoin Structure

1,3-Dichloro-5,...

CAS#:118-52-5

Learn More
Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2>113, p. 263 Anm.4

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles6

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

a-Chlorination of Acetophenones Using 1, 3-Dichloro-5, 5-Dimethylhydantoin. Xu Z, et al.

Synth. Commun. 36(2) , 255-8, (2006)

Oxidation of urazoles with 1, 3-dihalo-5, 5-dimethylhydantoin, both in solution and under solvent-free conditions. Zolfigol MA, et al.

Synlett 5 , 761-4, (2005)

Introduction of 3'-terminal nucleosides having a silyl-type linker into polymer supports without base protection.

J. Org. Chem. 74(7) , 2817-23, (2009)

New 3'-terminal deoxyribonucleoside-loading reagents having a silyl-type linker were developed. They were effectively introduced into polymer supports under the conditions of Huisgen [3 + 2] cycloaddi...

 1,3-Dichloro-5,5-dimethylhydantoinBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293
Name: Adrenergic beta2 receptor (ADRB2) small molecule antagonists, cell-based qHTS assay
Source: 824
External Id: ADRB2713
Total 207, Current Page 1 of 21
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione DCDMH
EINECS 204-258-7
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione
1,3-dichloro-5,5-dimethylhydantoin
1,3-Dichloro-5,5-dimethyl hydantoin
MFCD00003190
1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione

 1,3-Dichloro-5,5-dimethylhydantoin | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the melting point of 1,3-Dichloro-5,5-dimethylhydantoin?
A: Melting point of 1,3-Dichloro-5,5-dimethylhydantoin is 132-134 °C(lit.).
Q: What is the polar surface area (PSA) of 1,3-Dichloro-5,5-dimethylhydantoin?
A: Polar surface area (PSA) of 1,3-Dichloro-5,5-dimethylhydantoin is 40.62000.
Q: What is the molecular weight of 1,3-Dichloro-5,5-dimethylhydantoin?
A: Molecular weight of 1,3-Dichloro-5,5-dimethylhydantoin is 197.019.
Q: What is the InChIKey of 1,3-Dichloro-5,5-dimethylhydantoin?
A: InChIKey of 1,3-Dichloro-5,5-dimethylhydantoin is KEQGZUUPPQEDPF-UHFFFAOYSA-N.
Q: What are the downstream products of 1,3-Dichloro-5,5-dimethylhydantoin?
A: Related downstream products(CAS) of 1,3-Dichloro-5,5-dimethylhydantoin: 3840-27-5;2675-78-7;26245-56-7;73075-59-9;633-99-8;77-48-5;13101-92-3;10443-43-3;88-06-2;623-12-1.
Q: How is the water solubility of 1,3-Dichloro-5,5-dimethylhydantoin?
A: Water solubility of 1,3-Dichloro-5,5-dimethylhydantoin: 0.21 g/100 mL (25 ºC).
Q: What is the boiling point of 1,3-Dichloro-5,5-dimethylhydantoin?
A: Boiling point of 1,3-Dichloro-5,5-dimethylhydantoin is 214.7±23.0 °C at 760 mmHg.
Q: What is the LogP of 1,3-Dichloro-5,5-dimethylhydantoin?
A: LogP of 1,3-Dichloro-5,5-dimethylhydantoin is 1.36.
Q: What is the CAS number of 1,3-Dichloro-5,5-dimethylhydantoin?
A: CAS number of 1,3-Dichloro-5,5-dimethylhydantoin is 118-52-5.
Q: What is the safety information for 1,3-Dichloro-5,5-dimethylhydantoin?
A: Safety information for 1,3-Dichloro-5,5-dimethylhydantoin: S26-S36-S45-S36/37/39-S17-S61.

 1,3-Dichloro-5,5-dimethylhydantoinfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides 1,3-Dichloro-5,5-dimethylhydantoin(CAS#:118-52-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 1,3-Dichloro-5,5-dimethylhydantoin are included as well.>> amp version: 1,3-Dichloro-5,5-dimethylhydantoin

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