Duocarmycin A

Modify Date: 2024-01-05 15:39:46

Duocarmycin A structure	Common Name	Duocarmycin A
	CAS Number	118292-34-5	Molecular Weight	507.49200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₅N₃O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Duocarmycin A

Duocarmycin A, which is one of well-known antitumor antibiotics, efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

Name	duocarmycin a
Synonym	More Synonyms

Description	Duocarmycin A, which is one of well-known antitumor antibiotics, efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Apoptosis >> Caspase
Target	Procaspase-3 Caspase-9
References	[1]. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.

Molecular Formula	C₂₆H₂₅N₃O₈
Molecular Weight	507.49200
Exact Mass	507.16400
PSA	136.26000
LogP	1.74720

(+)-Dunnione

(+)-duocarmycin A

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Duocarmycin A
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Duocarmycin A
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Duocarmycin A
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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