JNJ-40413269
Modify Date: 2024-04-09 17:50:35
JNJ-40413269 structure
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Common Name | JNJ-40413269 | ||
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| CAS Number | 1184847-16-2 | Molecular Weight | 393.794 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H15ClF3N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ-40413269JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively; exhibits a robust dose-dependent decrease in mechanical allodynia in the spinal nerve ligation model of neuropathic pain; strongly raises the brain levels of AEA, PEA and OEA. |
| Name | JNJ-40413269 |
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| Description | JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively; exhibits a robust dose-dependent decrease in mechanical allodynia in the spinal nerve ligation model of neuropathic pain; strongly raises the brain levels of AEA, PEA and OEA. |
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| References | References 1. Keith JM, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1280-4. View Related Products by Target FAAH |
| Molecular Formula | C19H15ClF3N3O |
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| Molecular Weight | 393.794 |