Buformin hydrochloride
Modify Date: 2024-01-01 18:55:01
Buformin hydrochloride structure
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Common Name | Buformin hydrochloride | ||
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| CAS Number | 1190-53-0 | Molecular Weight | 193.67800 | |
| Density | N/A | Boiling Point | 322.7ºC at 760 mmHg | |
| Molecular Formula | C6H16ClN5 | Melting Point | 174-177ºC | |
| MSDS | Chinese USA | Flash Point | 148.9ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
Use of Buformin hydrochlorideBuformin hydrochloride (1-Butylbiguanide hydrochloride) is a potent and orally active biguanide antidiabetic agent, an AMPK activator. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1]. |
| Name | Buformin Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Buformin hydrochloride (1-Butylbiguanide hydrochloride) is a potent and orally active biguanide antidiabetic agent, an AMPK activator. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1]. |
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| Related Catalog | |
| In Vitro | Buformin hydrochloride (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC50 values of 246.7 μM and 98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively[1]. Buformin hydrochloride (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells[1]. Buformin hydrochloride (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells[1]. Cell Viability Assay[1] Cell Line: ErbB-2-overexpressing SKBR3 and BT474 cells Concentration: 0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300 μM, 1, 3, or 10 mM Incubation Time: 5 days Result: Reduced cell viability in erbB-2-overexpressing breast cells. Cell Cycle Analysis[1] Cell Line: ErbB-2-overexpressing SKBR3 and BT474 cells Concentration: 0.5 mM; 1 mM; 3 mM Incubation Time: 48 hours Result: Increased cells arresting in G0/G1 phase. Western Blot Analysis[1] Cell Line: ErbB-2-overexpressing SKBR3 and BT474 cells Concentration: 0 mM, 0.1 mM, 0.3 mM, 1 mM, or 3 mM Incubation Time: 24 hours Result: Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner. |
| In Vivo | Buformin hydrochloride (oral administation; 7.6 mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice[1]. Animal Model: Female MMTV-erbB-2 transgenic mice[1] Dosage: 7.6 mmol/kg Administration: Oral administation; 7 days Result: Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice. |
| References |
| Boiling Point | 322.7ºC at 760 mmHg |
|---|---|
| Melting Point | 174-177ºC |
| Molecular Formula | C6H16ClN5 |
| Molecular Weight | 193.67800 |
| Flash Point | 148.9ºC |
| Exact Mass | 193.10900 |
| PSA | 97.78000 |
| LogP | 2.27750 |
| Vapour Pressure | 0.000275mmHg at 25°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H318-H335 |
| Precautionary Statements | P280-P301 + P312 + P330-P305 + P351 + P338 + P310 |
| Hazard Codes | Xi |
| Risk Phrases | 22-43-36 |
| Safety Phrases | 36/39-46 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2925290090 |
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
| EINECS 214-723-6 |
| butyl-biguanide hydrochloride |