ADRA1D receptor agonist 1
Modify Date: 2024-01-11 11:28:03
ADRA1D receptor agonist 1 structure
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Common Name | ADRA1D receptor agonist 1 | ||
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| CAS Number | 1191908-14-1 | Molecular Weight | 337.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H14Cl2N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ADRA1D receptor agonist 1ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1]. |
| Name | ADRA1D receptor agonist 1 |
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| Description | ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1]. |
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| Related Catalog | |
| Target |
Ki: 1.6 nM (α1D adrenoceptor)[1] |
| In Vitro | ADRA1D receptor agonist 1 shows low hERG inhibition[1]. ADRA1D receptor agonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs [1]. |
| In Vivo | ADRA1D receptor agonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO[1]. Animal Model: Rat with bladder outlet obstruction (BOO)[1] Dosage: 4.4 µg/kg Administration: Intravenous injection Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. |
| References |
| Molecular Formula | C15H14Cl2N4O |
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| Molecular Weight | 337.20 |