Donepezil Hydrochloride

Modify Date: 2024-01-02 10:59:21

Donepezil Hydrochloride Structure
Donepezil Hydrochloride structure
Common Name Donepezil Hydrochloride
CAS Number 120011-70-3 Molecular Weight 415.953
Density N/A Boiling Point 527.9ºC at 760 mmHg
Molecular Formula C24H30ClNO3 Melting Point 220-222ºC
MSDS USA Flash Point 273.1ºC

 Use of Donepezil Hydrochloride


Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine. IC50 Value:Target: AChEIt is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats.

 Names

Name donepezil hydrochloride
Synonym More Synonyms

 Donepezil Hydrochloride Biological Activity

Description Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine. IC50 Value:Target: AChEIt is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats.
Related Catalog
References

[1]. Dubois B, et al. Donepezil in Parkinson's disease dementia: A randomized, double-blind efficacy and safety study. Mov Disord. 2012 Sep 1;27(10):1230-8.

[2]. Zaidel L, et al. Donepezil effects on hippocampal and prefrontal functional connectivity in Alzheimer's disease: preliminary report. J Alzheimers Dis. 2012 Jan 1;31(0):S221-6.

[3]. Tsuno N. Donepezil in the treatment of patients with Alzheimer's disease. Expert Rev Neurother. 2009 May;9(5):591-8.

[4]. Halabe Bucay A. Donepezil (aricept) as a treatment for anorexia nervosa: a very feasible therapeutic possibility. Expert Opin Investig Drugs. 2009 May;18(5):569-71.

 Chemical & Physical Properties

Boiling Point 527.9ºC at 760 mmHg
Melting Point 220-222ºC
Molecular Formula C24H30ClNO3
Molecular Weight 415.953
Flash Point 273.1ºC
Exact Mass 415.191437
PSA 38.77000
LogP 5.10100
Vapour Pressure 3.11E-11mmHg at 25°C
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR UN 2811
HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride
MFCD00881312
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride (1:1)
2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride (1:1)
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one hydrochloride
5,6-Dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydro-1H-inden-1-one Hydrochloride
2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)
2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-onhydrochlorid
2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride
1H-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride
2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine Hydrochloride
Donepezil HCl
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride
Donepezil hydrochloride
2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one hydrochloride (1:1)
Donepezil
Top Suppliers:I want be here





Get all suppliers and price by the below link:

Donepezil Hydrochloride suppliers


Price: ¥312/50mg

Reference only. check more Donepezil Hydrochloride price