sEH inhibitor-1

Modify Date: 2024-01-12 20:38:41

sEH inhibitor-1 Structure
sEH inhibitor-1 structure
Common Name sEH inhibitor-1
CAS Number 1208549-68-1 Molecular Weight 371.354
Density 1.4±0.1 g/cm3 Boiling Point 470.8±45.0 °C at 760 mmHg
Molecular Formula C17H20F3N3O3 Melting Point N/A
MSDS N/A Flash Point 238.5±28.7 °C

 Use of sEH inhibitor-1


sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].

 Names

Name 1-(1-(cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
Synonym More Synonyms

 sEH inhibitor-1 Biological Activity

Description sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].
Related Catalog
Target

sEH[1]

References

[1]. Liu JY, et al. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013;48(4-5):619-627.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 470.8±45.0 °C at 760 mmHg
Molecular Formula C17H20F3N3O3
Molecular Weight 371.354
Flash Point 238.5±28.7 °C
Exact Mass 371.145691
PSA 70.67000
LogP 2.15
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.556

 Synonyms

Urea, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-
1-[1-(Cyclopropylcarbonyl)-4-piperidinyl]-3-[4-(trifluoromethoxy)phenyl]urea
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