Ebastine-d5

Modify Date: 2024-01-22 09:13:58

Ebastine-d5 structure	Common Name	Ebastine-d5
	CAS Number	1216953-13-7	Molecular Weight	469.658
	Density	1.1±0.1 g/cm3	Boiling Point	596.3±50.0 °C at 760 mmHg
	Molecular Formula	C₃₂H₃₉NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	314.5±30.1 °C

Use of Ebastine-d5

Ebastine-d5 (LAS-W 090-d5) is the deuterium labeled Ebastine. Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1][2].

Name	Ebastine-d5
Synonym	More Synonyms

Description	Ebastine-d5 (LAS-W 090-d5) is the deuterium labeled Ebastine. Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. J Sastre. Ebastine in allergic rhinitis and chronic idiopathic urticarial. Allergy. 2008 Dec;63 Suppl 89:1-20. [3]. Fu-Ming Tsai, et al. Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation. Biomed Res Int. 2019 Feb 11;2019:6360503. [4]. Fujii, et al. Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats. Arzneimittelforschung. 1994 Apr;44(4):527-38.

Density	1.1±0.1 g/cm3
Boiling Point	596.3±50.0 °C at 760 mmHg
Molecular Formula	C₃₂H₃₉NO₂
Molecular Weight	469.658
Flash Point	314.5±30.1 °C
Exact Mass	469.298065
LogP	7.79
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.590

4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-[4-(2-methyl-2-propanyl)phenyl]-1-butanone

4-Diphenylmethoxy-1-[3-(4-tert-butylbenzoyl)propyl]piperidine

4'-tert-Butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone

1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one

MFCD00865661

1-Butanone, 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-

1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone

Ebastin

Ebastine

Ebastine-d5

Use of Ebastine-d5

Names

Ebastine-d5 Biological Activity

Chemical & Physical Properties

Synonyms