prepro-thyrotropin releasing hormone (160-169)

Modify Date: 2024-01-07 18:42:39

prepro-thyrotropin releasing hormone (160-169) Structure
prepro-thyrotropin releasing hormone (160-169) structure
 Common Name prepro-thyrotropin releasing hormone (160-169)
CAS Number 122018-91-1 Molecular Weight 1198.301
Density 1.4±0.1 g/cm3 Boiling Point 1696.2±65.0 °C at 760 mmHg
Molecular Formula C54H75N11O18S Melting Point N/A
MSDS N/A Flash Point 979.6±34.3 °C

 Use of prepro-thyrotropin releasing hormone (160-169)


Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release[1].

 Names

Name L-Seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-L-threonine
Synonym More Synonyms

  Biological Activity

Description Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release[1].
Related Catalog
In Vitro 在大鼠垂体前叶细胞的原代培养物中，Prepro-TRH-(160-169) (Ps4) 能够在 15 秒内迅速增加细胞内 Ca2+ 浓度（[Ca2+] i) [2]。
In Vivo 在氨基甲酸乙酯麻醉的大鼠中，Prepro-TRH-(160-169)（Ps4；100 ng、150 ng 和 200 ng；注入背运动核 (DMN)）通过肽和位点特异性的作用增强 DMN 诱发的胃酸分泌中的 TRH： 是肽和位点特异性的[1]。
References

[1]. H Yang, et al. Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus. Neurosci Lett. 1994 Jun 6;174(1):43-6.  

[2]. J P Roussel, et al. Somatostatin blocks the potentiation of TRH-induced TSH secretion from perifused pituitary fragments and the change in intracellular calcium concentrations from dispersed pituitary cells elicited by prepro-TRH (PS4) or by tri-iodothyronine. J Mol Endocrinol. 1997 Aug;19(1):87-97.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1696.2±65.0 °C at 760 mmHg
Molecular Formula C54H75N11O18S
Molecular Weight 1198.301
Flash Point 979.6±34.3 °C
Exact Mass 1197.501221
LogP 0.58
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.619

 Synonyms

L-Threonine, L-seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-
L-Seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-L-threonine
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Chemsrc provides CAS#:122018-91-1 MSDS, density, melting point, boiling point, structure, etc. Its name is prepro-thyrotropin releasing hormone (160-169)>> amp version: prepro-thyrotropin releasing hormone (160-169)

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