PS 423

Modify Date: 2024-01-19 13:58:26

PS 423 Structure
PS 423 structure
Common Name PS 423
CAS Number 1221964-37-9 Molecular Weight 524.445
Density N/A Boiling Point N/A
Molecular Formula C25H23F3O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PS 423


PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210; inhibits glucose uptake in C2C12 myoblasts; inhibits S6K but not PKB/Akt downstream signaling in muscle cells.

 Names

Name PS 423

 PS 423 Biological Activity

Description PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210; inhibits glucose uptake in C2C12 myoblasts; inhibits S6K but not PKB/Akt downstream signaling in muscle cells.
References References 1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63. 2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. View Related Products by Target PDK1

 Chemical & Physical Properties

Molecular Formula C25H23F3O9
Molecular Weight 524.445