PS-432
Modify Date: 2024-02-04 17:19:42
PS-432 structure
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Common Name | PS-432 | ||
|---|---|---|---|---|
| CAS Number | 2083630-26-4 | Molecular Weight | 494.947 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 662.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C25H19ClN2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 354.5±34.3 °C | |
Use of PS-432PS-432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively; has no inhibitory activity against PKCα, PKCβ, PKCδ and PKCθ nor the activity of related kinases such as PDK1, PKB/Akt, RSK1, MSK1 and Aurora A; inhibits the proliferation of the lung cancer cell lines A549 (IC50=14.8 ± 4.2 uM) and A427 (IC50=10.4± 0.3 uM) as well as androgen-independent prostate cancer cell line DU145 (IC50 = 20.8 ± 9.0 uM); well tolerated in vivo. |
| Name | PS432 |
|---|---|
| Synonym | More Synonyms |
| Description | PS-432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively; has no inhibitory activity against PKCα, PKCβ, PKCδ and PKCθ nor the activity of related kinases such as PDK1, PKB/Akt, RSK1, MSK1 and Aurora A; inhibits the proliferation of the lung cancer cell lines A549 (IC50=14.8 ± 4.2 uM) and A427 (IC50=10.4± 0.3 uM) as well as androgen-independent prostate cancer cell line DU145 (IC50 = 20.8 ± 9.0 uM); well tolerated in vivo. |
|---|---|
| References | References 1. Arencibia JM, et al. ACS Chem Biol. 2017 Feb 17;12(2):564-573. View Related Products by Target PKC |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 662.5±65.0 °C at 760 mmHg |
| Molecular Formula | C25H19ClN2O5S |
| Molecular Weight | 494.947 |
| Flash Point | 354.5±34.3 °C |
| Exact Mass | 494.070313 |
| LogP | 5.81 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.686 |
| 1H-Pyrrole-3-carboxylic acid, 2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-, ethyl ester |
| 2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-1H-pyrrole-3-carboxylic acid ethyl ester |
| PS432 |
| Ethyl 2-[5-(4-chlorophenyl)-2-furyl]-4-hydroxy-1-(6-methyl-1,3-benzothiazol-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate |