PS 1145 dihydrochloride

Modify Date: 2025-08-23 18:46:04

PS 1145 dihydrochloride Structure
PS 1145 dihydrochloride structure
 Common Name PS 1145 dihydrochloride
CAS Number 1049743-58-9 Molecular Weight 395.670
Density N/A Boiling Point N/A
Molecular Formula C17H13Cl3N4O Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of PS 1145 dihydrochloride


PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].

 Names

Name N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide,dih ydrochloride
Synonym More Synonyms

 PS 1145 dihydrochloride Biological Activity

Description PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].
Related Catalog
Target

IC50: 88 nM (IκB kinase-2)[1]

References

[1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068.

 Chemical & Physical Properties

Molecular Formula C17H13Cl3N4O
Molecular Weight 395.670
Exact Mass 394.015503
PSA 74.16000
LogP 6.00480
InChIKey QTDCBADLGJZBHP-UHFFFAOYSA-N
SMILES Cl.Cl.O=C(Nc1cc(Cl)cc2c1[nH]c1cnccc12)c1cccnc1

 Synonyms

N-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide dihydrochloride
3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, hydrochloride (1:2)
PS-1145 Dihydrochloride
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