Tyrphostin 47
Modify Date: 2024-01-05 13:31:08
Tyrphostin 47 structure
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Common Name | Tyrphostin 47 | ||
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| CAS Number | 122520-86-9 | Molecular Weight | 220.248 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 474.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C10H8N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 240.8±31.5 °C | |
Use of Tyrphostin 47Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3]. |
| Name | 3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile |
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| Synonym | More Synonyms |
| Description | Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3]. |
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| Related Catalog | |
| In Vitro | Tyrphostin AG213 (25 μM, 50 μM, 和 75 μM; 24 h, 48 h, 和 96 h) 增加人脐静脉内皮细胞 (HUVEC) 单层的伤口闭合时间[1]。 Tyrphostin AG213 (100 μM; 1 h) 干扰 HUVEC 焦点粘附和应力纤维形成[1]。 Tyrphostin AG213 (100 μM; 24 h) 抑制 HUVEC 中 pp125FAK 的粘附相关酪氨酸磷酸化[1]。 Tyrphostin AG213 (10 μM; 24 h) 抑制酪氨酸激酶活性，并且呈剂量和时间依赖关系地抑制 HT-29 细胞活力[2]。 |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 474.5±55.0 °C at 760 mmHg |
| Molecular Formula | C10H8N2O2S |
| Molecular Weight | 220.248 |
| Flash Point | 240.8±31.5 °C |
| Exact Mass | 220.030655 |
| PSA | 122.36000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.780 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: 50 mg/mL, clear, orange |
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| WGK Germany | 3 |
| 2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- |
| Tyrphostin 47 |
| IN1038 |
| (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenethioamide |
| (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide |