Tyrphostin AG 1112
Modify Date: 2024-01-12 19:22:37
Tyrphostin AG 1112 structure
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Common Name | Tyrphostin AG 1112 | ||
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| CAS Number | 153150-84-6 | Molecular Weight | 274.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H10N6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Tyrphostin AG 1112Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2]. |
| Name | TYRPHOSTIN AG 1112 |
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| Description | Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2]. |
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| Related Catalog | |
| In Vitro | Tyrphostin AG1112 (0-100 μM) dose-dependently induces differentiation also induce specific growth arrest[1]. |
| References |
| Molecular Formula | C15H10N6 |
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| Molecular Weight | 274.28 |
| Appearance of Characters | solid |
| Storage condition | −20°C |
| Hazard Codes | Xn |
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| Risk Phrases | 36/37/38-40 |
| Safety Phrases | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
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Protein kinase inhibitors as a therapeutic modality.
Acc. Chem. Res. 36(6) , 462-9, (2003) Most of the signal transduction pathways are mediated by protein kinases regulating every aspect of cell function. Mutations which deregulate their expression or their function or both result in cance... |
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Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.
Blood 82(12) , 3524-9, (1993) We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210bcr-abl tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid diff... |