SCH 39166 hydrobromide
Modify Date: 2024-01-15 00:10:19
SCH 39166 hydrobromide structure
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Common Name | SCH 39166 hydrobromide | ||
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| CAS Number | 1227675-51-5 | Molecular Weight | 394.73 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21BrClNO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SCH 39166 hydrobromideSCH 39166 hydrobromide (SCH391660) is potent and selective antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. SCH 39166 hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). SCH 39166 hydrobromide can be used for the research of schizophrenia, cocaine addition, and obesity[1]. |
| Name | (6aS,13bR)-11-Chloro-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepin-12-ol hydrobromide (1:1) |
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| Synonym | More Synonyms |
| Description | SCH 39166 hydrobromide (SCH391660) is potent and selective antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. SCH 39166 hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). SCH 39166 hydrobromide can be used for the research of schizophrenia, cocaine addition, and obesity[1]. |
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| Related Catalog | |
| Target |
D1 Receptor:1.2 nM (Ki) D5 Receptor:2.0 nM (Ki) D2 Receptor:980 nM (Ki) D4 Receptor:5520 nM (Ki) 5-HT Receptor:80 nM (Ki) Alpha-2A adrenergic receptor:731 nM (Ki) |
| In Vitro | SCH 39166 (2 μM) hydrobromide completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2]. |
| In Vivo | SCH 39166 (0.003-0.3 mg/kg; a single s.c.) hydrobromide abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats[3]. Animal Model: Male young adult Long-Evans rats were injected with Nicotine[3] Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg) Result: Dose-dependently reduced pressing on both active and inactive levers. |
| References |
| Molecular Formula | C19H21BrClNO |
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| Molecular Weight | 394.73 |
| Exact Mass | 393.049500 |
| 5H-Benzo[d]naphth[2,1-b]azepin-12-ol, 11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-, (6aS,13bR)-, hydrobromide (1:1) |
| (6aS,13bR)-11-Chloro-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepin-12-ol hydrobromide (1:1) |
| SCH39166 |