Alosetron
Modify Date: 2024-01-02 13:57:14
Alosetron structure
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Common Name | Alosetron | ||
|---|---|---|---|---|
| CAS Number | 122852-42-0 | Molecular Weight | 294.35100 | |
| Density | 1.34 g/cm3 | Boiling Point | 648.1ºC at 760 mmHg | |
| Molecular Formula | C17H18N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 345.8ºC | |
Use of AlosetronAlosetron is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia. |
| Name | alosetron |
|---|---|
| Synonym | More Synonyms |
| Description | Alosetron is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia. |
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| Related Catalog | |
| References |
| Density | 1.34 g/cm3 |
|---|---|
| Boiling Point | 648.1ºC at 760 mmHg |
| Molecular Formula | C17H18N4O |
| Molecular Weight | 294.35100 |
| Flash Point | 345.8ºC |
| Exact Mass | 294.14800 |
| PSA | 53.92000 |
| LogP | 2.34620 |
| Vapour Pressure | 1.1E-16mmHg at 25°C |
| Index of Refraction | 1.706 |
| Storage condition | 2-8℃ |
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~%
Alosetron CAS#:122852-42-0 |
| Literature: US5221687 A1, ; |
|
~28%
Alosetron CAS#:122852-42-0 |
| Literature: AUSPEX PHARMACEUTICALS, INC. Patent: US2010/113478 A1, 2010 ; Location in patent: Page/Page column 13 ; |
|
~63%
Alosetron CAS#:122852-42-0 |
| Literature: ORCHID CHEMICALS and PHARMACEUTICALS LIMITED Patent: US2012/178937 A1, 2012 ; Location in patent: Page/Page column 3 ; |
|
~%
Alosetron CAS#:122852-42-0 |
| Literature: US5196534 A1, ; US 5196534 A |
![2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one structure](https://image.chemsrc.com/caspic/207/122852-75-9.png)
| UNII-13Z9HTH115 |
| 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one |
| Alosetron HCl |