Mps1-IN-2

Modify Date: 2024-01-10 18:39:39

Mps1-IN-2 structure	Common Name	Mps1-IN-2
	CAS Number	1228817-38-6	Molecular Weight	480.602
	Density	1.3±0.1 g/cm3	Boiling Point	772.7±70.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₆N₆O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	421.1±35.7 °C

Use of Mps1-IN-2

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.

Name	Msp1-IN-2
Synonym	More Synonyms

Description	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Mps1 Signaling Pathways >> Cytoskeleton >> Mps1 Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK) Research Areas >> Cancer
Target	Mps1:12 nM (Kd) GAK:140 nM (Kd) PLK1:61 nM (Kd) PLK3:1600 nM (Kd) PLK4:3100 nM (Kd) STK33:5000 nM (Kd)
In Vitro	Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with Kds of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells[1].
Kinase Assay	The kinase binding assay is used to assess compound binding to TTK by monitoring displacement of a fluorescently labeled, ATP site-directed kinase inhibitor (Kinase Tracer 236) from the kinase active site. Each 15 μL assay contains 5 nM TTK, variable amounts of test compound (Mps1-IN-2), 30 nM Kinase Tracer 236, 2 nM Eu-anti-GST Antibody, and 1% DMSO (residual from compound dilution) in Kinase Buffer A (50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% Brij-35). Binding assays are initiated by addition of 5 μL of test compound (from 2-fold dilution series) to 5 μL of a kinase/antibody mixture, followed by addition of 5 μL of antibody. Assay plates are read using using standard Eu-based TR-FRET settings with excitation at 340 nm and emission monitored at 615 nm (donor) and 665 nm (acceptor). Emission intensities are measured over a 200 µs window following a 100 µs post-excitation delay[1].
References	[1]. Kwiatkowski N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68.

Density	1.3±0.1 g/cm3
Boiling Point	772.7±70.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₆N₆O₃
Molecular Weight	480.602
Flash Point	421.1±35.7 °C
Exact Mass	480.284882
PSA	94.06000
LogP	2.05
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.633
Storage condition	2-8℃

RIDADR	NONH for all modes of transport

6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-

9-Cyclopentyl-2-{[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino}-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

Mps1-IN-2

DC Chemicals Limited
China
Product Name: Mps1-IN-2
Price: $850.0/100mg $1500.0/250mg $2600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Mps1-IN-2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $119/10mM*1mLinDMSO

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Mps1-IN-2

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