Maleic hydrazide

Modify Date: 2024-01-02 17:30:12

Maleic hydrazide structure	Common Name	Maleic hydrazide
	CAS Number	123-33-1	Molecular Weight	112.087
	Density	1.5±0.1 g/cm3	Boiling Point	477.2±25.0 °C at 760 mmHg
	Molecular Formula	C₄H₄N₂O₂	Melting Point	306-308 ºC
	MSDS	Chinese USA	Flash Point	242.4±23.2 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Maleic hydrazide

Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins[1][2].

Name	maleic hydrazide
Synonym	More Synonyms

Description	Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Maleic hydrazide is used in agriculture-in despite its known effect as a mutagenic and clastogenic agent. Maleic hydrazide had lower IC50 values for all cell lines compared to Ethephon. Maleic hydrazide also showed least cytotoxicity on Vero cells, followed by Hep2 and HepG2 cells[3].
In Vivo	Maleic hydrazide has a low acute toxicity by oral, dermal, and inhalation routes of exposure[3].
References	[1]. Venezian A, et al. The Influence of the Plant Growth Regulator Maleic Hydrazide on Egyptian Broomrape Early Developmental Stages and Its Control Efficacy in Tomato under Greenhouse and Field Conditions. Front Plant Sci. 2017;8:691. Published 2017 May 16. [2]. Swietlińska Z, et al. Cytotoxic effects of maleic hydrazide. Mutat Res. 1978;55(1):15-30. [3]. Yurdakok B, et al. Cytotoxic effects of etephon and maleic hydrazide in Vero, Hep2, HepG2 cells. Drug Chem Toxicol. 2014;37(4):459-465.

Density	1.5±0.1 g/cm3
Boiling Point	477.2±25.0 °C at 760 mmHg
Melting Point	306-308 ºC
Molecular Formula	C₄H₄N₂O₂
Molecular Weight	112.087
Flash Point	242.4±23.2 °C
Exact Mass	112.027275
PSA	65.72000
LogP	-0.14
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.640
Water Solubility	6 g/L

Maleic hydrazide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR5950000

CHEMICAL NAME :: 3,6-Pyridazinedione, 1,2-dihydro-

CAS REGISTRY NUMBER :: 123-33-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 38

MOLECULAR FORMULA :: C4-H4-N2-O2

MOLECULAR WEIGHT :: 112.10

WISWESSER LINE NOTATION :: T6VMMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg/4W-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Immunological Including Allergic - increase in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 ug/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,1,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,173,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,173,1974 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84780 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 124 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84780 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 1440 (estimated)

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H335-H341
Precautionary Statements	P261-P281-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R36/37/38;R40
Safety Phrases	S26-S36-S45-S36/37/39
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	UR5950000
HS Code	2928000090

Maleic anhydride

CAS#:108-31-6

~92%

Maleic hydrazide

CAS#:123-33-1

Literature: Edelmann, Michael J.; Raimundo, Jean-Manuel; Utesch, Nils F.; Diederich, Francois; Boudon, Corinne; Gisselbrecht, Jean-Paul; Gross, Maurice Helvetica Chimica Acta, 2002 , vol. 85, # 7 p. 2195 - 2213

3-[(3-carboxypr...

CAS#:5343-00-0

Maleic hydrazide

CAS#:123-33-1

Literature: Journal of the American Chemical Society, , vol. 80, p. 3790

Maleic acid

CAS#:110-16-7

Maleic hydrazide

CAS#:123-33-1

Literature: Journal of the American Chemical Society, , vol. 80, p. 3790

N/A

CAS#:18259-51-3

Maleic hydrazide

CAS#:123-33-1

Literature: Chemical and Pharmaceutical Bulletin, , vol. 7, p. 938,940

Maleic anhydride

CAS#:108-31-6

Hydrazine hydrate

CAS#:7803-57-8

acetic acid

CAS#:64-19-7

Maleic hydrazide

CAS#:123-33-1

Literature: Journal of the American Chemical Society, , vol. 80, p. 3790

Precursor 5
CAS#:108-31-6 Maleic anhydride CAS#:5343-00-0 3-[(3-carboxypr... CAS#:110-16-7 Maleic acid CAS#:7803-57-8 Hydrazine hydrate
CAS#:64-19-7 acetic acid
DownStream 10
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CAS#:1945-76-2 [1(6H),3'-Bipyr... CAS#:2797-52-6 3(2H)-Pyridazin... CAS#:15456-83-4 3(2H)-Pyridazin... CAS#:5436-01-1 3,6-Pyridazined...
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HS Code	2933990011
Summary	2933990011 o,o-diethyl o-quinoxalin-2-yl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Mixture genotoxicity of 2,4-dichlorophenoxyacetic acid, acrylamide, and maleic hydrazide on human Caco-2 cells assessed with comet assay.

J. Toxicol. Environ. Health A 78(6) , 369-80, (2015)

Assessment of genotoxic properties of chemicals is mainly conducted only for single chemicals, without taking mixture genotoxic effects into consideration. The current study assessed mixture effects o...

Assessment of the chemical, microbiological and toxicological aspects of post-processing water from underground coal gasification.

Ecotoxicol. Environ. Saf. 108 , 294-301, (2014)

The purpose of this paper is to provide a comprehensive characterisation (including chemical, microbiological and toxicological parameters) of water after the underground coal gasification (UCG) proce...

Glyphosate, alachor and maleic hydrazide have genotoxic effect on Trigonella foenum-graecum L.

Bull. Environ. Contam. Toxicol. 88(5) , 659-65, (2012)

In the present study effects of herbicides glyphosate (GP), alachlor (AL) and maleic hydrazide (MH) is studied on mitotic cells of Trigonella foenum-graecum L. Seeds of T. foenum-graecum L. treated wi...

Vondalhyd

Yadi

MG-T

3(2H)-Pyridazinone, 6-hydroxy-

cis-Butenedioic acid hydrazide

MH-30

EINECS 204-619-9

3,6-Dihydroxypyridazine

3,6-dioxo-1,2,3,6-tetrahydropyridazine

1,2-Dihydro-3,6-pyridazinedione

T6VMMVJ

1,2-dihydro 3,6-pyridazinedione

pyridazine-3,6-diol

gotax

1,2,3,6-Tetrahydro-3,6-dioxopyridazine

MFCD00006665

1,2-dihydropyridazine-3,6-dione

Bos MH

KMH

6-hydroxy-2H-pyridazin-3-one

Fazor

Maleic hydrazine

T6NMVJ FQ

Yake

Hydrazide maleique

1,2-Dihydro-3,6-pyridazinedione,3,6-Dihydroxypyridazine,3,6-Pyridazinediol

Maleic Hydrazide

MH-40

3,6-Pyridazinedione, 1,2-dihydro-

mAh

3,6-Pyridazinediol

Maleic acid cyclic hydrazide

T6NNJ CQ FQ

Maleic Acid Hydrazide

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China
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