Maleic acid

Modify Date: 2026-06-30 08:44:27

Maleic acid Structure
Maleic acid structure
 Common Name Maleic acid
CAS Number 110-16-7 Molecular Weight 116.072
Density 1.5±0.1 g/cm3 Boiling Point 355.5±25.0 °C at 760 mmHg
Molecular Formula C4H4O4 Melting Point 134-138ºC
MSDS Chinese USA Flash Point 183.0±19.7 °C
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Use of Maleic acid


Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name maleic acid
Synonym More Synonyms

 Maleic acid Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
Related Catalog
Target

Human Endogenous Metabolite

GAD

In Vitro The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal[2].
References

[1]. Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9.

[2]. Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms; Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb;69:96-104.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5±0.1 g/cm3
Boiling Point 355.5±25.0 °C at 760 mmHg
Melting Point 134-138ºC
Molecular Formula C4H4O4
Molecular Weight 116.072
Flash Point 183.0±19.7 °C
Exact Mass 116.010956
PSA 74.60000
LogP -0.01
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.526
InChIKey VZCYOOQTPOCHFL-UPHRSURJSA-N
SMILES O=C(O)C=CC(=O)O
Storage condition Store at RT.
Stability Stable. Combustible. Incompatible with strong oxidizing agents, bases.
Water Solubility 790 g/L (25 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OM9625000
CHEMICAL NAME :
Maleic acid
CAS REGISTRY NUMBER :
110-16-7
BEILSTEIN REFERENCE NO. :
0605762
LAST UPDATED :
199710
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C4-H4-O4
MOLECULAR WEIGHT :
116.08
WISWESSER LINE NOTATION :
QV1U1VQ -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
708 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>720 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1560 mg/kg
TOXIC EFFECTS :
Behavioral - tremor

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Fibroblast
DOSE/DURATION :
20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 183,89,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84505 No. of Facilities: 1840 (estimated) No. of Industries: 22 No. of Occupations: 27 No. of Employees: 17036 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84505 No. of Facilities: 2076 (estimated) No. of Industries: 36 No. of Occupations: 45 No. of Employees: 30064 (estimated) No. of Female Employees: 11590 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302 + H312-H315-H317-H318-H335
Precautionary Statements P280-P301 + P312 + P330-P305 + P351 + P338 + P310
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S28-S37
RIDADR UN 2215
WGK Germany 1
RTECS OM9625000
Packaging Group III
HS Code 2917190090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles122

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies.

Biochim. Biophys. Acta 1848(1 Pt B) , 329-33, (2015)

Membrane protein spectroscopic studies are challenging due to the difficulty introduced in preparing homogenous and functional hydrophobic proteins incorporated into a lipid bilayer system. Traditiona...

BoHV-4 immediate early 1 gene is a dispensable gene and its product is not a bone marrow stromal cell antigen 2 counteracting factor.

BMC Vet. Res. 11 , 224, (2015)

Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus whose genome was cloned as Bacterial Artificial Chromosome (BAC) and exploited as a gene delivery vector for vaccine purposes. Although BoHV-4 genom...

Inhibition of NOS-NO System Prevents Autoimmune Orchitis Development in Rats: Relevance of NO Released by Testicular Macrophages in Germ Cell Apoptosis and Testosterone Secretion.

PLoS ONE 10 , e0128709, (2015)

Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO) is a m...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(2Z)-2-Butenedioic acid
cis-2-Butenedioic Acid
2-Butenedioicacid (2Z)-
MFCD00063177
EINECS 203-742-5
Maleic acid
cis-Butenedioic acid,Toxilic acid
Maleic acid [NA2215]
(2Z)-But-2-enedioic acid

 Maleic acid | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of maleic acid?
A: InChIKey of maleic acid is VZCYOOQTPOCHFL-UPHRSURJSA-N.
Q: What is the safety information for maleic acid?
A: Safety information for maleic acid: S26-S28-S37.
Q: How is the water solubility of maleic acid?
A: Water solubility of maleic acid: 790 g/L (25 ºC).
Q: What is the melting point of maleic acid?
A: Melting point of maleic acid is 134-138ºC.
Q: What is the SMILES notation of maleic acid?
A: SMILES notation of maleic acid is O=C(O)C=CC(=O)O.
Q: What is the CAS number of maleic acid?
A: CAS number of maleic acid is 110-16-7.
Q: What are the downstream products of maleic acid?
A: Related downstream products(CAS) of maleic acid: 1063-55-4;1115-52-2;110-17-8;71653-06-0;56-40-6;74-89-5;617-45-8;302-72-7;107-95-9;1092939-15-5.
Q: What is the LogP of maleic acid?
A: LogP of maleic acid is -0.01.
Q: What are the storage conditions for maleic acid?
A: Storage conditions for maleic acid: Store at RT.
Q: What English synonyms does maleic acid have?
A: English synonyms of maleic acid: (2Z)-2-Butenedioic acid, cis-2-Butenedioic Acid, 2-Butenedioicacid (2Z)-, MFCD00063177, EINECS 203-742-5, Maleic acid, cis-Butenedioic acid,Toxilic acid, Maleic acid [NA2215], (2Z)-But-2-enedioic acid.

 Maleic acidfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Maleic acid suppliers

Price: ￥550/10 mM * 1 mL in DMSO

Reference only. check more Maleic acid price

Related Compounds: More...
N-[(2Z)-3-methyl-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-phenoxyacetamide
929851-88-7
2-(4-fluorophenoxy)-N-[4-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,2,5-oxadiazol-3-yl]propanamide
912909-94-5
(2Z)-2-(4-methylbenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl diphenylcarbamate
623116-06-3
(2Z)-2-(4-methylbenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl 4-chlorobenzenesulfonate
929470-76-8
(Z)-2-(2-methoxybenzylidene)-3-oxo-2,3-dihydrobenzofuran-6-yl 4-methoxybenzenesulfonate
929470-54-2
(2Z)-2-(2-ethoxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl cyclohexanecarboxylate
623115-96-8
[4-(1H-benzimidazol-2-yl)piperidin-1-yl](5-bromo-3-methyl-1-benzofuran-2-yl)methanone
920443-87-4
(2Z)-3-oxo-2-[4-(propan-2-yl)benzylidene]-2,3-dihydro-1-benzofuran-6-yl 4-chlorobenzenesulfonate
929412-10-2
3-Methyl-5-(8-quinolylmethylene)-2-thioxo-1,3-thiazolidin-4-one
38707-72-1
(2Z)-2-(2-chloro-6-fluorobenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl 4-methoxybenzenesulfonate
929470-80-4
Chemsrc provides Maleic acid(CAS#:110-16-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Maleic acid are included as well.>> amp version: Maleic acid

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved