Biperidene hydrochloride
Modify Date: 2024-01-05 12:22:05
Biperidene hydrochloride structure
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Common Name | Biperidene hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1235-82-1 | Molecular Weight | 347.922 | |
| Density | N/A | Boiling Point | 462.1ºC at 760 mmHg | |
| Molecular Formula | C21H30ClNO | Melting Point | 101ºC | |
| MSDS | Chinese USA | Flash Point | 224.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Biperidene hydrochlorideBiperiden(KL 373) Hcl is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.Target: M1 receptorsBiperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on M1 receptors [2].Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not [3].Clinical indications: parkinsonismFDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness |
| Name | biperiden hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Biperiden(KL 373) Hcl is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.Target: M1 receptorsBiperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on M1 receptors [2].Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not [3].Clinical indications: parkinsonismFDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness |
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| Related Catalog | |
| References |
| Boiling Point | 462.1ºC at 760 mmHg |
|---|---|
| Melting Point | 101ºC |
| Molecular Formula | C21H30ClNO |
| Molecular Weight | 347.922 |
| Flash Point | 224.5ºC |
| Exact Mass | 347.201599 |
| PSA | 23.47000 |
| LogP | 4.70230 |
| Vapour Pressure | 2.45E-09mmHg at 25°C |
| Water Solubility | DMSO: >20mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| RIDADR | NONH for all modes of transport |
| RTECS | TN3706000 |
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| Biperidene hydrochloride |
| biperidine hydrochloride |
| Biperiden (Hydrochloride) |