ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Modify Date: 2024-03-01 07:37:11

ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate structure	Common Name	ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
	CAS Number	123629-42-5	Molecular Weight	306.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₈N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells[1].

Name	ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (en)5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-, ethyl ester (en)
Synonym	More Synonyms

Description	gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology
Target	HIV-1:7.5 μM (IC50) HIV-1:112.93 μM (CC50)
References	[1]. Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526.

Molecular Formula	C₁₅H₁₈N₂O₅
Molecular Weight	306.31
Exact Mass	306.12200
PSA	96.89000
LogP	2.24940

Ethyl acetoacetate

CAS#:141-97-9

Vanillin

CAS#:121-33-5

Urea

CAS#:57-13-6

~98%

ethyl 4-(4-hydr...

CAS#:123629-42-5

Literature: Alvim, Haline G. O.; De Lima, Tatiani B.; De Oliveira, Heibbe C. B.; Gozzo, Fabio C.; De MacEdo, Julio L.; Abdelnur, Patricia V.; Silva, Wender A.; Neto, Brenno A. D. ACS Catalysis, 2013 , vol. 3, # 7 p. 1420 - 1430

Precursor 3
CAS#:141-97-9 Ethyl acetoacetate CAS#:121-33-5 Vanillin CAS#:57-13-6 Urea
DownStream 0

1,2,3,4-tetrahydro-3-quinolinamine

3-amino-1,2,3,4-tetrahydroquinoline

1,2,3,4-tetrahydroquinoline-3-amine

ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Use of ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms