CGP 36742

Modify Date: 2024-01-09 14:11:18

CGP 36742 Structure
CGP 36742 structure
Common Name CGP 36742
CAS Number 123690-78-8 Molecular Weight 179.19700
Density N/A Boiling Point N/A
Molecular Formula C7H18NO2P Melting Point N/A
MSDS USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of CGP 36742


CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1].

 Names

Name 3-aminopropyl(n-butyl)-phosphinic acid
Synonym More Synonyms

 CGP 36742 Biological Activity

Description CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1].
Related Catalog
Target

IC50: 32 μM (GABAB)[1]

References

[1]. Nowak G, et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149(5):581-90.

 Chemical & Physical Properties

Molecular Formula C7H18NO2P
Molecular Weight 179.19700
Exact Mass 179.10800
PSA 73.13000
LogP 2.10600

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS SZ4113300

 Synonyms

3-aminopropyl-(n-butyl)-phosphinic acid
(3-amino-propyl)-butyl-phosphinic acid
(3-aminopropyl)(n-butyl)phosphinic acid
3-amino-propyl-n-butyl-phosphinic acid