CGP 53353

Modify Date: 2024-01-09 19:23:59

CGP 53353 structure	Common Name	CGP 53353
	CAS Number	145915-60-2	Molecular Weight	365.33
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₃F₂N₃O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of CGP 53353

CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1].

Name	5,6-bis(4-fluoroanilino)isoindole-1,3-dione
Synonym	More Synonyms

Description	CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Metabolic Disease Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCβII:0.41 mM (IC50) PKCβI:3.8 mM (IC50)
In Vitro	CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells[1]. CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage[1]. Cell Proliferation Assay Cell Line: A10 (cell proliferation induced by glucose)[1] Concentration: 1 μM Incubation Time: 48-96 hours Result: Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
References	[1]. Yamamoto M, et al. Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation. Am J Physiol Cell Physiol. 2000;279(3):C587-C595.

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₀H₁₃F₂N₃O₂
Molecular Weight	365.33
Exact Mass	365.097595
PSA	70.23000
LogP	3.89
Index of Refraction	1.703

CGP 53353 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

CGP 53 353

DAPH 2

5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione DAPH 2

PKCbetaII/EGFR Inhibitor

1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-

4,5-bis(4-fluoroanilino)phthalimide

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Pam2CSK4 Biotin

DC Chemicals Limited
China
Product Name: CGP-53353
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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