(3S,5R)-Rosuvastatin
Modify Date: 2025-08-23 15:42:51
(3S,5R)-Rosuvastatin structure
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Common Name | (3S,5R)-Rosuvastatin | ||
|---|---|---|---|---|
| CAS Number | 1242184-42-4 | Molecular Weight | 481.53800 | |
| Density | 1.368±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H28FN3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (3S,5R)-Rosuvastatin(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3]. |
| Name | rosuvastatin |
|---|---|
| Synonym | More Synonyms |
| Description | (3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3]. |
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| Related Catalog | |
| Target |
IC50: 11 nM (HMG-CoA)[1] and 195 nM (hERG)[2] |
| References |
| Density | 1.368±0.06 g/cm3 |
|---|---|
| Molecular Formula | C22H28FN3O6S |
| Molecular Weight | 481.53800 |
| Exact Mass | 481.16800 |
| PSA | 149.30000 |
| LogP | 3.48250 |
| Water Solubility | Very slightly soluble (0.17 g/L) (25 ºC) |
| (3S,5R)-Rosuvastatin Sodium Salt |
| (3S,5R)-Rosuvastatin |
| Rosuvastatin Acid Enantiomer |